{"id":"W3166074522","doi":"10.1158/1078-0432.ccr-20-4175","title":"Heterogeneity in <i>NECTIN4</i> Expression Across Molecular Subtypes of Urothelial Cancer Mediates Sensitivity to Enfortumab Vedotin","year":2021,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Bladder and Urothelial Cancer Treatments","field":"Medicine","cited_by":155,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Decipher Biosciences (Canada)","funders":"National Center for Advancing Translational Sciences; Council for Science, Technology and Innovation; A.P. Giannini Foundation; Svenska Läkaresällskapet; National Cancer Institute; National Institutes of Health; Vetenskapsrådet; Giannini Foundation of Agricultural Economics","keywords":"Urothelial cancer; Cancer; Oncology; Medicine; Internal medicine; Cancer research; Bladder cancer; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002305609,0.0002147156,0.0007733117,0.0001082542,0.000100563,0.00002787836,0.0001613207,0.0002443663,0.0003872282],"category_scores_gemma":[0.001400979,0.0001841184,0.0002510192,0.0008140864,0.0002987391,0.00006996703,0.0003647112,0.0008516919,0.00003414835],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002638084,"about_ca_system_score_gemma":0.001845855,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00504773,"about_ca_topic_score_gemma":0.008705201,"domain_scores_codex":[0.9957802,0.0008621714,0.0007450659,0.0007992717,0.00103289,0.000780425],"domain_scores_gemma":[0.997239,0.0007813147,0.00009155348,0.000631911,0.0007727586,0.000483452],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003913328,0.001135925,0.6754897,0.0002759083,0.0001636514,0.0009545835,0.0005745079,0.0001250937,0.2836309,0.00001555938,0.001030854,0.03268994],"study_design_scores_gemma":[0.00370143,0.0005525218,0.1990752,0.0005628997,0.00003689443,0.00001171642,0.0001562887,0.00003714038,0.7922989,0.00006531983,0.003331751,0.000169942],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993255,0.002732907,0.00003720282,0.001983238,0.0004645803,0.0007292808,0.0002713394,0.00002744724,0.0004990288],"genre_scores_gemma":[0.9960764,0.00160129,0.0002138652,0.0009291083,0.0004985454,0.0002942816,0.00001944608,0.00004817001,0.0003188798],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.508668,"threshold_uncertainty_score":0.7630691,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1590056249802177,"score_gpt":0.5352728762811759,"score_spread":0.3762672513009582,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}