{"id":"W3166074522","doi":"10.1158/1078-0432.ccr-20-4175","title":"Heterogeneity in <i>NECTIN4</i> Expression Across Molecular Subtypes of Urothelial Cancer Mediates Sensitivity to Enfortumab Vedotin","year":2021,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Bladder and Urothelial Cancer Treatments","field":"Medicine","cited_by":155,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Decipher Biosciences (Canada)","funders":"National Center for Advancing Translational Sciences; Council for Science, Technology and Innovation; A.P. Giannini Foundation; Svenska Läkaresällskapet; National Cancer Institute; National Institutes of Health; Vetenskapsrådet; Giannini Foundation of Agricultural Economics","keywords":"Urothelial cancer; Cancer; Oncology; Medicine; Internal medicine; Cancer research; Bladder cancer; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002673757,0.000124207,0.0002957935,0.0002947983,0.0002323441,0.0005128129,0.0001774713,0.0002064449,0.0008818309],"category_scores_gemma":[0.0004584715,0.0001325835,0.0002475508,0.0003200767,0.0002660864,0.0001664071,0.0002657193,0.0003067314,0.0002094735],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003307267,"about_ca_system_score_gemma":0.0002326678,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00131239,"about_ca_topic_score_gemma":0.001536729,"domain_scores_codex":[0.9997404,0.00004496197,0.0000291203,0.00007532378,0.00005836908,0.00005186263],"domain_scores_gemma":[0.9996972,0.00005899079,0.0001110302,0.00004296516,0.00005184184,0.00003799183],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0007237783,0.0000394282,0.183527,0.0001461213,0.0001219582,0.000148024,0.0001298021,0.0003509999,0.807881,0.00008641397,0.0002120374,0.006633539],"study_design_scores_gemma":[0.00001933905,0.000378646,0.8594173,0.00002028552,0.0001409849,0.001124489,0.0004143734,0.001295058,0.1356594,0.000121796,0.001397036,0.00001120388],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987925,0.0002731829,0.000309615,0.00002153947,0.000001420674,0.000006819501,0.0003156806,0.00001165287,0.0002675225],"genre_scores_gemma":[0.9988812,0.0001035063,0.0002179627,0.00002779851,0.000001823004,0.00000945647,0.0005939499,0.000006452025,0.0001580471],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00131239,"threshold_uncertainty_score":0.002950013,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1590056249802177,"score_gpt":0.5352728762811759,"score_spread":0.3762672513009582,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}