{"id":"W3166105596","doi":"10.1093/nar/gkab475","title":"The role of CTCF in the organization of the centromeric 11p15 imprinted domain interactome","year":2021,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"Genetic Syndromes and Imprinting","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"National Institutes of Health; Alex's Lemonade Stand Foundation for Childhood Cancer; National Cancer Institute; Damon Runyon Cancer Research Foundation","keywords":"CTCF; Genomic imprinting; Biology; Chromatin; Imprinting (psychology); Genetics; DNA methylation; Chromosome conformation capture; Bivalent chromatin; Gene silencing; Gene; Transcription factor; Gene expression; Chromatin remodeling; Enhancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00084098,0.00006835144,0.00009369052,0.00003219765,0.0001323221,0.00003298069,0.0006320043,0.00006903916,0.00005385697],"category_scores_gemma":[0.0007798891,0.00003703676,0.00005859475,0.0007306944,0.0001950528,0.000002436626,0.0005398503,0.000212458,0.000004980684],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001601938,"about_ca_system_score_gemma":0.0001380143,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004821542,"about_ca_topic_score_gemma":0.00003596348,"domain_scores_codex":[0.9985309,0.0004495262,0.0002336269,0.0001761728,0.0003514666,0.0002583474],"domain_scores_gemma":[0.9988493,0.00008539321,0.00007108073,0.0006019398,0.0003691483,0.00002314495],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00000568024,0.00005210932,0.04369988,0.00001078201,0.00001921867,7.171114e-7,0.0005436678,0.000005205015,0.9477448,0.0003216035,0.00007234412,0.007523973],"study_design_scores_gemma":[0.0002906252,0.00009060105,0.292819,0.00002637722,0.000003908518,0.00003557412,0.007810631,0.00008492251,0.6779438,0.0004271811,0.0204081,0.00005923518],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970761,0.0005289093,0.00004962887,0.0006477275,0.00005870526,0.0001658979,0.000003226911,0.000001477297,0.00146835],"genre_scores_gemma":[0.999371,0.0002335341,0.0001189951,0.00003312378,0.00003757681,0.000006371044,0.000008426401,0.0000136401,0.0001773458],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.269801,"threshold_uncertainty_score":0.1510315,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01129466602189863,"score_gpt":0.2872660307382114,"score_spread":0.2759713647163128,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}