{"id":"W3166105596","doi":"10.1093/nar/gkab475","title":"The role of CTCF in the organization of the centromeric 11p15 imprinted domain interactome","year":2021,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"Genetic Syndromes and Imprinting","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"National Institutes of Health; Alex's Lemonade Stand Foundation for Childhood Cancer; National Cancer Institute; Damon Runyon Cancer Research Foundation","keywords":"CTCF; Genomic imprinting; Biology; Chromatin; Imprinting (psychology); Genetics; DNA methylation; Chromosome conformation capture; Bivalent chromatin; Gene silencing; Gene; Transcription factor; Gene expression; Chromatin remodeling; Enhancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007236418,0.0001857461,0.0001061332,0.0002221775,0.0002071949,0.0003147895,0.0002177048,0.0002306153,0.0005355921],"category_scores_gemma":[0.0001618823,0.0001253906,0.00007399145,0.0001160332,0.0002343987,0.00015313,0.0002322413,0.0001589275,0.0001649696],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004178802,"about_ca_system_score_gemma":0.0002285816,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002869357,"about_ca_topic_score_gemma":0.005820277,"domain_scores_codex":[0.9999309,0.000007932066,0.000002982643,0.00001852597,0.00001854766,0.00002112011],"domain_scores_gemma":[0.9999374,0.00001123897,0.00001677246,0.000006858237,0.000005660747,0.0000221314],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008954903,0.000007419073,0.005463978,0.0000272868,0.000007558139,0.0003917467,0.00005203938,0.0003981546,0.9876094,0.0009156896,0.00006946392,0.004967716],"study_design_scores_gemma":[0.00003611151,0.0001446254,0.1718792,0.00002200189,0.00003264931,0.002666869,0.0001272143,0.009916564,0.8067738,0.001263868,0.007117825,0.00001929558],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910274,0.001967381,0.005041908,0.0001338891,0.00001177029,0.000007475327,0.0001258999,0.0000647102,0.001619574],"genre_scores_gemma":[0.9979722,0.000221155,0.0009450596,0.00001640992,0.000003143208,0.000003091899,0.000100827,0.000005897203,0.0007323457],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002869357,"threshold_uncertainty_score":0.005705357,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01129466602189863,"score_gpt":0.2872660307382114,"score_spread":0.2759713647163128,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}