{"id":"W3166129227","doi":"10.1126/sciadv.abf0797","title":"Spatiotemporally confined red light-controlled gene delivery at single-cell resolution using adeno-associated viral vectors","year":2021,"lang":"en","type":"article","venue":"Science Advances","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Albert-Ludwigs-Universität Freiburg; Canada's Michael Smith Genome Sciences Centre; Medizinischen Hochschule Hannover; Deutsche Forschungsgemeinschaft; Rice University","keywords":"Gene delivery; Resolution (logic); Adeno-associated virus; Gene; Virology; Cell; Computational biology; Vector (molecular biology); Biology; Genetic enhancement; Genetics; Computer science; Recombinant DNA; Artificial intelligence","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006591291,0.0001809535,0.0002331463,0.0001321511,0.0004814997,0.00008059645,0.0003683981,0.0001091639,0.00005063921],"category_scores_gemma":[0.000385449,0.0001730193,0.0001108072,0.0006398731,0.0003460335,0.00003568709,0.0002012267,0.00009361874,0.00001101675],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002624795,"about_ca_system_score_gemma":0.0008866938,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002193803,"about_ca_topic_score_gemma":0.000466413,"domain_scores_codex":[0.9977621,0.0001823027,0.0002899799,0.0006612462,0.0005578941,0.0005464249],"domain_scores_gemma":[0.9987496,0.00002388765,0.000188985,0.0004042858,0.0004947889,0.0001384867],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001469636,0.000100946,0.0006287119,0.000005294469,0.00001876542,0.00001387697,0.00004594532,0.002004671,0.9951414,0.000001121003,0.00006069426,0.0005088816],"study_design_scores_gemma":[0.002295815,0.0009980394,0.0002327876,0.00001498641,0.00001376506,0.000006706464,0.00005204213,0.001033655,0.9928958,0.00003441769,0.002202408,0.0002195289],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931771,0.005213038,0.0001642189,0.0003240227,0.0002727576,0.0002392663,0.00001214586,0.00002364623,0.0005737997],"genre_scores_gemma":[0.9969187,0.0001575566,0.001095277,0.0001884911,0.0001249561,0.00001233798,0.00008763405,0.00001950348,0.001395578],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005055481,"threshold_uncertainty_score":0.7055521,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01889390414939347,"score_gpt":0.2817557717709271,"score_spread":0.2628618676215336,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}