{"id":"W3166129227","doi":"10.1126/sciadv.abf0797","title":"Spatiotemporally confined red light-controlled gene delivery at single-cell resolution using adeno-associated viral vectors","year":2021,"lang":"en","type":"article","venue":"Science Advances","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Albert-Ludwigs-Universität Freiburg; Canada's Michael Smith Genome Sciences Centre; Medizinischen Hochschule Hannover; Deutsche Forschungsgemeinschaft; Rice University","keywords":"Gene delivery; Resolution (logic); Adeno-associated virus; Gene; Virology; Cell; Computational biology; Vector (molecular biology); Biology; Genetic enhancement; Genetics; Computer science; Recombinant DNA; Artificial intelligence","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002622046,0.0003563768,0.0003094515,0.0002306967,0.0001747992,0.0007396382,0.0004046321,0.0004241133,0.0005465499],"category_scores_gemma":[0.0001585739,0.0002696866,0.0002250682,0.0001725842,0.0004073397,0.0004532017,0.0004131247,0.0008719529,0.0004495161],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004096848,"about_ca_system_score_gemma":0.0003636246,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006902204,"about_ca_topic_score_gemma":0.001103506,"domain_scores_codex":[0.9997991,0.00001946445,0.00002005648,0.00007287801,0.00005837551,0.00003018585],"domain_scores_gemma":[0.9998692,0.00003319208,0.00004423216,0.00001833562,0.00001656757,0.00001848225],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000006342212,0.000005099363,0.00002155744,0.00001338226,0.000001037338,0.00001204612,0.00001031228,0.0001018306,0.9990114,0.0001607813,0.00001354164,0.0006426327],"study_design_scores_gemma":[0.000005673607,0.00003755047,0.0002348497,0.0000039708,0.0000059676,0.00007874465,0.00001431566,0.002652741,0.9945111,0.00009731654,0.002350356,0.00000741875],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7881498,0.003372887,0.202011,0.0003035374,0.00013142,0.0001637587,0.0005417271,0.0009770128,0.004348805],"genre_scores_gemma":[0.8651041,0.002767859,0.1254156,0.0001091439,0.00003204455,0.0001579182,0.0004205372,0.0001794632,0.005813251],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007396382,"threshold_uncertainty_score":0.002972424,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01889390414939347,"score_gpt":0.2817557717709271,"score_spread":0.2628618676215336,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}