{"id":"W3166148623","doi":"10.1038/s41467-021-23630-x","title":"High throughput screening identifies SOX2 as a super pioneer factor that inhibits DNA methylation maintenance at its binding sites","year":2021,"lang":"en","type":"article","venue":"Nature Communications","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Clinical Research Institute","funders":"Institute of Genetics and Genomics of Geneva; Novartis Stiftung für Medizinisch-Biologische Forschung; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Université de Genève; Novartis Foundation","keywords":"DNA methylation; Throughput; High-throughput screening; DNA; Methylation; Computational biology; SOX2; Transcription factor; Biology; Genetics; Chemistry; Computer science; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000253919,0.0003690928,0.000466574,0.0003326112,0.0001808904,0.0002663118,0.0002684588,0.0003082834,0.001297283],"category_scores_gemma":[0.0002546682,0.0001526172,0.0003044687,0.0002654398,0.0001773211,0.0000814974,0.0001560456,0.0002973072,0.0004177841],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002231692,"about_ca_system_score_gemma":0.0002458242,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001230681,"about_ca_topic_score_gemma":0.002241486,"domain_scores_codex":[0.9997944,0.00002680516,0.00001028036,0.00003894233,0.00008912067,0.00004040508],"domain_scores_gemma":[0.9998645,0.00005822964,0.0000150573,0.00001692244,0.00001250726,0.00003281123],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007999939,0.00004247645,0.0003145681,0.00001074776,0.000007413216,0.00004193638,0.000003606827,0.00008947296,0.9978606,0.00002157959,0.00004459848,0.001482971],"study_design_scores_gemma":[0.00002362962,0.0004408894,0.004295228,0.000001484384,0.00002252528,0.0002286607,0.000008746363,0.001505352,0.9920997,0.0000216578,0.001347828,0.000004356795],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9858103,0.001389728,0.01006323,0.00009802714,0.00002056858,0.00008878135,0.0009090421,0.0001823559,0.001437906],"genre_scores_gemma":[0.9840098,0.0008242854,0.007728978,0.00007253834,0.00001424433,0.00006030092,0.002867651,0.00004174075,0.0043806],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001297283,"threshold_uncertainty_score":0.004339874,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04005804040092617,"score_gpt":0.3150813632936746,"score_spread":0.2750233228927484,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}