{"id":"W3166171733","doi":"10.1200/jco.2021.39.15_suppl.tps5612","title":"ADAGIO: A phase IIb, open-label, single-arm, multicenter study assessing the efficacy and safety of adavosertib (AZD1775) as treatment for recurrent or persistent uterine serous carcinoma.","year":2021,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Renal and related cancers","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Medicine; KRAS; Serous fluid; Internal medicine; Clear cell carcinoma; Oncology; Neuroblastoma RAS viral oncogene homolog; Carcinoma; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001220206,0.001389064,0.001804719,0.0005316138,0.0003098681,0.001222063,0.0009482558,0.001448853,0.005683018],"category_scores_gemma":[0.000686073,0.0005550888,0.001509681,0.0004054515,0.0007424867,0.0007718083,0.0003302393,0.002998345,0.001509427],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007268823,"about_ca_system_score_gemma":0.001028857,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007552714,"about_ca_topic_score_gemma":0.002122117,"domain_scores_codex":[0.9997395,0.0001057685,0.00001126303,0.00005264138,0.00002912219,0.00006176538],"domain_scores_gemma":[0.9996763,0.0000469633,0.00007739226,0.00002671711,0.00002643674,0.0001461606],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7740981,0.02612273,0.003145979,0.00381949,0.003333993,0.0002367739,0.00029113,0.002089017,0.04015879,0.0007250949,0.008957162,0.1370217],"study_design_scores_gemma":[0.7709257,0.2083445,0.005537552,0.0001494282,0.001098443,0.0003501074,0.00008937521,0.001073628,0.002820437,0.000402115,0.009164358,0.00004446177],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.949191,0.02775387,0.001876286,0.001657833,0.0008083687,0.006528952,0.004728105,0.0005624641,0.006893236],"genre_scores_gemma":[0.9641404,0.01104319,0.003444935,0.00322669,0.0002997415,0.005998751,0.004547282,0.00008085625,0.007218126],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005683018,"threshold_uncertainty_score":0.01901156,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2001823358987698,"score_gpt":0.5105117308033281,"score_spread":0.3103293949045583,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}