{"id":"W3166241138","doi":"10.1039/d0sc05843b","title":"An engineered biosynthetic–synthetic platform for production of halogenated indolmycin antibiotics","year":2021,"lang":"en","type":"article","venue":"Chemical Science","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver Biotech (Canada); University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Genome British Columbia; Michael Smith Health Research BC","keywords":"Antibiotics; Combinatorial chemistry; Biochemical engineering; Production (economics); Chemistry; Biochemistry; Engineering","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002165699,0.0003857154,0.0002745478,0.0002083129,0.0001756271,0.0003710271,0.0004584446,0.0002879951,0.0007302559],"category_scores_gemma":[0.0001665166,0.0001886183,0.0002775566,0.0002591701,0.0002133926,0.000259913,0.0004604531,0.000746514,0.0006266754],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003095289,"about_ca_system_score_gemma":0.0004325888,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004335185,"about_ca_topic_score_gemma":0.0007267011,"domain_scores_codex":[0.9998043,0.00002696038,0.00001755031,0.00003467841,0.00007861665,0.00003784792],"domain_scores_gemma":[0.9998657,0.00001543116,0.00004001287,0.00002092277,0.00001676191,0.00004113243],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004178044,0.00002807953,0.00004403318,0.00002473333,0.00000272581,0.00005557346,0.00001311264,0.0002277299,0.9977815,0.0002780921,0.00002960714,0.001473207],"study_design_scores_gemma":[0.0000150525,0.000202366,0.0002903188,0.000003883539,0.000007136017,0.0001204595,0.00001046805,0.001255343,0.9947718,0.00006590175,0.003248872,0.000008454018],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8777394,0.0007930004,0.1148355,0.0002028228,0.0001158295,0.0003770977,0.001432303,0.000763771,0.003740386],"genre_scores_gemma":[0.9169704,0.0007533996,0.07716221,0.00005301108,0.00001776882,0.0001778358,0.001413401,0.0001219206,0.003329918],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007302559,"threshold_uncertainty_score":0.002442896,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01942310244254808,"score_gpt":0.2672996313872353,"score_spread":0.2478765289446873,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}