{"id":"W3166259184","doi":"10.1158/1078-0432.ccr-21-0358","title":"Blood Biomarker Landscape in Patients with High-risk Nonmetastatic Castration-Resistant Prostate Cancer Treated with Apalutamide and Androgen-Deprivation Therapy as They Progress to Metastatic Disease","year":2021,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Prevention of Organ Failure; University of British Columbia","funders":"Janssen Research and Development","keywords":"Prostate cancer; Androgen receptor; Medicine; Androgen deprivation therapy; Enzalutamide; Internal medicine; Oncology; Biomarker; Proportional hazards model; Metastasis; Cancer; Androgen; Antiandrogen; Biology; Hormone","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001701691,0.0001493698,0.0004370042,0.0003695961,0.0002024886,0.0004074253,0.0001653607,0.0002780795,0.0008190317],"category_scores_gemma":[0.0007098388,0.0001197097,0.0001878467,0.0005014409,0.0001597539,0.0002426198,0.000113187,0.0002952162,0.0001257947],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002982646,"about_ca_system_score_gemma":0.0001560633,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009202627,"about_ca_topic_score_gemma":0.001240699,"domain_scores_codex":[0.9998096,0.00004930345,0.00001630551,0.00005256951,0.0000391385,0.00003317592],"domain_scores_gemma":[0.9996282,0.00007628055,0.0001451002,0.00001745497,0.00004211496,0.00009089676],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00370177,0.0001246583,0.9825273,0.00002354535,0.0001218997,0.0003330154,0.00009034535,0.0001411502,0.005411052,0.00002707777,0.0001808415,0.007317387],"study_design_scores_gemma":[0.00004976157,0.0009870105,0.9970799,0.000002911256,0.0000494318,0.000631563,0.00007405308,0.0003555199,0.0005278882,0.00002947688,0.0002082112,0.000004212046],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994235,0.0002624483,0.00004152004,0.00002072482,0.000002288169,0.000003750968,0.00008941675,0.000002636924,0.0001538157],"genre_scores_gemma":[0.9997097,0.00003529287,0.00002823577,0.00001967364,0.000004000974,0.000002987984,0.000145327,6.119009e-7,0.00005420211],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009202627,"threshold_uncertainty_score":0.002739906,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07527895759064986,"score_gpt":0.4244568030450357,"score_spread":0.3491778454543859,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}