{"id":"W3166268612","doi":"10.1101/2021.05.31.446406","title":"Differential microRNA expression analyses across two brain regions in Alzheimer’s disease","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"MicroRNA in disease regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Deutsche Forschungsgemeinschaft; National Natural Science Foundation of China; Alzheimer Society; Medical Research Council; Cure Alzheimer's Fund; National Science Foundation","keywords":"microRNA; Biology; Small RNA; Gene expression; Gene; Deep sequencing; Entorhinal cortex; Genetics; Neuroscience; Hippocampus; Genome","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002925469,0.0002576343,0.0004071922,0.0008821154,0.0002223951,0.0003604119,0.0001137509,0.0002341874,0.0006358372],"category_scores_gemma":[0.000292857,0.0001640803,0.0002963753,0.0005328049,0.0002244784,0.0001121666,0.0002297782,0.0001973616,0.0001898139],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001539081,"about_ca_system_score_gemma":0.0001455841,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000566533,"about_ca_topic_score_gemma":0.0009736806,"domain_scores_codex":[0.9998404,0.00001492168,0.00001928026,0.00007277288,0.00003125314,0.00002133319],"domain_scores_gemma":[0.9998491,0.00003906863,0.00004238159,0.00001560619,0.00003634616,0.00001746158],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001205025,0.00004023261,0.03725998,0.0002014466,0.0001681372,0.0003174521,0.0001966508,0.0001113377,0.9516764,0.00007811376,0.000136364,0.008608738],"study_design_scores_gemma":[0.00005249172,0.0005833348,0.7701853,0.00002911233,0.0005028938,0.00322706,0.0003196977,0.00139439,0.2203018,0.0004004852,0.002978114,0.00002526673],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994779,0.001413306,0.002423197,0.00001490919,0.00001137458,0.00002424812,0.0007885534,0.00003971701,0.0005056724],"genre_scores_gemma":[0.9935384,0.0005187016,0.004271613,0.00004725307,0.000009138498,0.00007328316,0.001113214,0.00002458331,0.0004037191],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008821154,"threshold_uncertainty_score":0.002127051,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02910216083636807,"score_gpt":0.303026995008695,"score_spread":0.2739248341723269,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}