{"id":"W3166274652","doi":"10.1200/jco.2021.39.15_suppl.5002","title":"Decreased fracture rate by mandating bone protecting agents in the EORTC 1333/PEACEIII trial combining Ra223 with enzalutamide versus enzalutamide alone: An updated safety analysis.","year":2021,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"","keywords":"Enzalutamide; Medicine; Prostate cancer; Denosumab; Population; Internal medicine; Adverse effect; Oncology; Randomized controlled trial; Incidence (geometry); FRAX; Asymptomatic; Surgery; Cancer; Osteoporosis; Androgen receptor; Bone mineral","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.007267022,0.0007653036,0.001415711,0.0006609458,0.0001881834,0.00109283,0.0007881648,0.0007807297,0.002587327],"category_scores_gemma":[0.006190244,0.0004276441,0.003796381,0.001131564,0.0003345862,0.0004844377,0.000369673,0.001800522,0.0003677599],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007718759,"about_ca_system_score_gemma":0.0008641895,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001159266,"about_ca_topic_score_gemma":0.003588939,"domain_scores_codex":[0.9970859,0.001734213,0.0002303879,0.0002710592,0.0005275941,0.0001509288],"domain_scores_gemma":[0.9949419,0.001793142,0.002165069,0.0004205199,0.0003767145,0.0003027378],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7425674,0.001552045,0.05531974,0.003754127,0.03102925,0.0001677682,0.0001392976,0.002099677,0.006096645,0.0004809595,0.009663143,0.14713],"study_design_scores_gemma":[0.3921737,0.1219834,0.3408913,0.001136221,0.1024041,0.001582658,0.0001592166,0.005398876,0.007488547,0.001929607,0.02461005,0.0002423366],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9133934,0.04988189,0.004952216,0.001721382,0.0003637872,0.002071651,0.02015478,0.000300189,0.007160557],"genre_scores_gemma":[0.9715537,0.008263925,0.002978351,0.00146329,0.0003501012,0.001105672,0.01243535,0.00006798247,0.001781622],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007267022,"threshold_uncertainty_score":0.03843218,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1346093577937221,"score_gpt":0.4848886222871188,"score_spread":0.3502792644933967,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}