{"id":"W3166361945","doi":"10.1039/d1ra04260b","title":"Methionine epimerization in cyclic peptides","year":2021,"lang":"en","type":"article","venue":"RSC Advances","topic":"Protein Hydrolysis and Bioactive Peptides","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Genome Prairie; Saskatoon Medical Imaging; University of Saskatchewan","funders":"Ministry of Agriculture - Saskatchewan; Genome Canada","keywords":"Epimer; Chemistry; Biomolecule; Methionine; Alkylation; Peptide; Amino acid; Cyclic peptide; Stereochemistry; Stereoisomerism; Combinatorial chemistry; Organic chemistry; Molecule; Biochemistry; Catalysis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001345862,0.0002710512,0.0001085949,0.0001113425,0.00009135521,0.0001031509,0.0001172177,0.0001689228,0.00080803],"category_scores_gemma":[0.0001563142,0.00007934426,0.0001282993,0.00009544448,0.000119491,0.0001507168,0.0001557744,0.0002720851,0.0001864157],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001019147,"about_ca_system_score_gemma":0.0001138789,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002430432,"about_ca_topic_score_gemma":0.0004120116,"domain_scores_codex":[0.9999342,0.00001262325,0.000004208322,0.00001915036,0.00001110832,0.00001881901],"domain_scores_gemma":[0.9999185,0.00001746529,0.00002679491,0.000008644996,0.00001434893,0.00001434186],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006298383,0.000003643755,0.00004253188,0.00002030979,0.000002149025,0.00003367852,0.00001385922,0.00002466138,0.9986444,0.00005758774,0.00001081652,0.001083289],"study_design_scores_gemma":[0.000003792387,0.0001251806,0.0006743128,0.000002302089,0.000003561018,0.0001146099,0.000008578686,0.0001200922,0.9979532,0.00002276548,0.0009693819,0.000002153392],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926431,0.001085524,0.004267957,0.00004833918,0.00001635717,0.00002632741,0.0001242429,0.00002918568,0.001759028],"genre_scores_gemma":[0.99407,0.0006338546,0.003506381,0.00004629145,0.000006873448,0.00001870147,0.0002157674,0.00001619728,0.00148591],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00080803,"threshold_uncertainty_score":0.00270313,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008930344026065943,"score_gpt":0.2717146735878297,"score_spread":0.2627843295617637,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}