{"id":"W3166379207","doi":"10.1200/jco.2021.39.15_suppl.1060","title":"Impact of duration of prior cyclin-dependent kinase 4/6 inhibitor (CDK4/6i) therapy on alpelisib (ALP) benefit in patients (pts) with hormone receptor–positive (HR+), human epidermal growth factor receptor-2–negative (HER2–), <i>PIK3CA</i>-mutated advanced breast cancer (ABC) from BYLieve.","year":2021,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"Novartis Pharmaceuticals Corporation","keywords":"Medicine; Fulvestrant; Internal medicine; Cohort; Letrozole; Oncology; Palbociclib; Proportional hazards model; Gastroenterology; Cancer; Breast cancer; Metastatic breast cancer; Estrogen receptor; Aromatase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007999029,0.0005399041,0.003051171,0.0002893067,0.00007741975,0.00001367835,0.0002756452,0.0005694204,0.0007254286],"category_scores_gemma":[0.001125355,0.0003849577,0.000702941,0.0005548766,0.0004854716,0.0006015566,0.00007485122,0.00157712,0.000005325029],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001418781,"about_ca_system_score_gemma":0.002067229,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001014866,"about_ca_topic_score_gemma":0.0005253778,"domain_scores_codex":[0.9927928,0.0008952053,0.004097967,0.0006444684,0.001064312,0.000505187],"domain_scores_gemma":[0.9881216,0.00205937,0.005610341,0.0003975476,0.003326686,0.0004844355],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.1574745,0.01305585,0.3923499,0.00004584824,0.002667564,0.0002449813,0.001933744,0.0007742274,0.1097606,0.0000217299,0.0001703055,0.3215007],"study_design_scores_gemma":[0.04940195,0.0298749,0.8750042,0.0008783426,0.0001840488,0.00003614863,0.0002760288,0.00001423931,0.04373559,0.0001703213,0.000102159,0.000322124],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949268,0.000785986,0.00007662345,0.001638833,0.0006655499,0.0008109969,0.0009735459,0.00001713186,0.0001045624],"genre_scores_gemma":[0.9931012,0.001954919,0.003286189,0.0005868627,0.0007733803,0.00002741111,0.0001414053,0.00008635456,0.00004227599],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4826542,"threshold_uncertainty_score":0.9998602,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03335397663975626,"score_gpt":0.3907142503515715,"score_spread":0.3573602737118153,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}