{"id":"W3166379207","doi":"10.1200/jco.2021.39.15_suppl.1060","title":"Impact of duration of prior cyclin-dependent kinase 4/6 inhibitor (CDK4/6i) therapy on alpelisib (ALP) benefit in patients (pts) with hormone receptor–positive (HR+), human epidermal growth factor receptor-2–negative (HER2–), <i>PIK3CA</i>-mutated advanced breast cancer (ABC) from BYLieve.","year":2021,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"Novartis Pharmaceuticals Corporation","keywords":"Medicine; Fulvestrant; Internal medicine; Cohort; Letrozole; Oncology; Palbociclib; Proportional hazards model; Gastroenterology; Cancer; Breast cancer; Metastatic breast cancer; Estrogen receptor; Aromatase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001079675,0.0002498168,0.0005624994,0.0002200931,0.0001877965,0.00057912,0.0003354075,0.0003815692,0.002178392],"category_scores_gemma":[0.001129939,0.0001704073,0.0007728309,0.0002143244,0.0002976223,0.0004723551,0.0003928826,0.0008374051,0.0002001271],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006213931,"about_ca_system_score_gemma":0.0008227822,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008832159,"about_ca_topic_score_gemma":0.003137441,"domain_scores_codex":[0.9996077,0.0001884304,0.00002022567,0.00006295866,0.00004241551,0.0000781917],"domain_scores_gemma":[0.9990311,0.0002983636,0.0001932782,0.00005522405,0.00002717887,0.0003948595],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.7370842,0.01428095,0.103654,0.0002750663,0.001025219,0.0001508605,0.0002642811,0.001911245,0.01892688,0.000272819,0.00189761,0.120257],"study_design_scores_gemma":[0.07680029,0.5695378,0.3337666,0.00009159193,0.001522607,0.00063934,0.0002934128,0.002597132,0.007328983,0.0004155354,0.006961418,0.00004530404],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983516,0.0006525147,0.000051857,0.00005741914,0.00001047669,0.0001065268,0.0002233208,0.000004604085,0.000541707],"genre_scores_gemma":[0.9981471,0.0003398096,0.0002218075,0.0001351191,0.00003016839,0.0001435682,0.0006105776,0.00000477016,0.0003669655],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002178392,"threshold_uncertainty_score":0.007287502,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03335397663975626,"score_gpt":0.3907142503515715,"score_spread":0.3573602737118153,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}