{"id":"W3166415013","doi":"10.1016/s1470-2045(21)00189-3","title":"Variation in the risk of colorectal cancer in families with Lynch syndrome: a retrospective cohort study","year":2021,"lang":"en","type":"article","venue":"The Lancet Oncology","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":118,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; National Health and Medical Research Council; Centre Léon Bérard; Universiti Sultan Zainal Abidin; National Institutes of Health; Ramsay Santé; Assistance publique-Hôpitaux de Paris; University of Colorado School of Medicine, Anschutz Medical Campus; Olav Thon Stiftelsen; Novo Nordisk Fonden; Instrumentariumin Tiedesäätiö; Universidad Pública de Navarra; Centro de Investigación Biomédica en Red de Cáncer; University of Cape Town; Aalborg Universitetshospital; Deutsche Krebshilfe; University of Texas MD Anderson Cancer Center; Leids Universitair Medisch Centrum; Emil Aaltosen Säätiö; City of Hope; Jane ja Aatos Erkon Säätiö; Universiti Sains Malaysia; Peter MacCallum Cancer Centre; Intelligent Manufacturing Research Center; Syöpäsäätiö; Financiadora de Estudos e Projetos; Novo Nordisk; Associazione Italiana per la Ricerca sul Cancro; Aalborg Universitet; Rigshospitalet; Kræftens Bekæmpelse; University of Melbourne; University of New South Wales; National Medical Research Council; Universiteit Leiden; Cancer Council NSW; National Cancer Centre of Singapore; Universiteit van Amsterdam; Universitair Medisch Centrum Groningen; Newcastle University; Health and Care Research Wales; KWF Kankerbestrijding; Cancer Research UK; Canadian Institutes of Health Research; Sigrid Juséliuksen Säätiö; University of Southampton; Amsterdam University Medical Centers; Institut National de la Santé et de la Recherche Médicale; Cancer Council Tasmania; Cedars-Sinai Medical Center; Swedish Cancer Foundation; University Hospitals of Leicester NHS Trust; Parc Geneteg Cymru; Svenska Läkaresällskapet; Gentofte Hospital; Deutsche Forschungsgemeinschaft; Medical Research Council; Nordea-fonden; National Institute for Health and Care Research; Odense Universitetshospital; Nebraska Department of Health and Human Services; Comprehensive Cancer Center, City of Hope; Kreftforeningen; South African Medical Research Council; Deutsches Krebsforschungszentrum; Academy of Finland; Suomen Lääketieteen Säätiö; University of Washington; Helsingin Yliopisto; Royal Adelaide Hospital; NIHR Maudsley Biomedical Research Centre; Rijksuniversiteit Groningen; U.S. Department of Health and Human Services; Creighton University; Instituto de Salud Carlos III; Ohio State University","keywords":"Colorectal cancer; Retrospective cohort study; Variation (astronomy); Lynch syndrome; Medicine; Cohort; Oncology; Cancer; Internal medicine; Demography; DNA mismatch repair; Sociology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001396822,0.0001253406,0.0006797983,0.00007080571,0.0000406744,0.000006093463,0.0001857735,0.00009676582,0.0001472705],"category_scores_gemma":[0.0003364171,0.00006781409,0.00003351602,0.0007573276,0.0001671835,0.00002181153,0.00005924312,0.0005255366,0.000002654595],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006697591,"about_ca_system_score_gemma":0.0005664871,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002879459,"about_ca_topic_score_gemma":0.04515687,"domain_scores_codex":[0.9980457,0.0008223484,0.000270973,0.0002775522,0.0003360825,0.000247334],"domain_scores_gemma":[0.9988368,0.0004707505,0.0001630043,0.0003583994,0.0001515803,0.00001943416],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0008423714,0.0004753228,0.9856584,0.00001934599,0.0001760586,0.0001670962,0.01086386,0.0003366548,0.0009445069,0.00006133604,0.00009395058,0.000361076],"study_design_scores_gemma":[0.003344605,0.002438608,0.9888424,0.00004002938,0.0001943663,0.0001582976,0.004183336,0.000159401,0.0002385373,0.0002248923,0.0001021882,0.00007335847],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932155,0.0002671265,0.000009098178,0.001590088,0.0002211921,0.001353373,0.00002621986,0.00001238731,0.003305024],"genre_scores_gemma":[0.9984482,0.0004084461,0.0002018698,0.0002669964,0.00008321773,0.0005333702,0.000003666307,0.00001274654,0.00004151169],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04227741,"threshold_uncertainty_score":0.9722665,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01803442414552895,"score_gpt":0.3129280167373696,"score_spread":0.2948935925918407,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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