{"id":"W3166415013","doi":"10.1016/s1470-2045(21)00189-3","title":"Variation in the risk of colorectal cancer in families with Lynch syndrome: a retrospective cohort study","year":2021,"lang":"en","type":"article","venue":"The Lancet Oncology","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":118,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; National Health and Medical Research Council; Centre Léon Bérard; Universiti Sultan Zainal Abidin; National Institutes of Health; Ramsay Santé; Assistance publique-Hôpitaux de Paris; University of Colorado School of Medicine, Anschutz Medical Campus; Olav Thon Stiftelsen; Novo Nordisk Fonden; Instrumentariumin Tiedesäätiö; Universidad Pública de Navarra; Centro de Investigación Biomédica en Red de Cáncer; University of Cape Town; Aalborg Universitetshospital; Deutsche Krebshilfe; University of Texas MD Anderson Cancer Center; Leids Universitair Medisch Centrum; Emil Aaltosen Säätiö; City of Hope; Jane ja Aatos Erkon Säätiö; Universiti Sains Malaysia; Peter MacCallum Cancer Centre; Intelligent Manufacturing Research Center; Syöpäsäätiö; Financiadora de Estudos e Projetos; Novo Nordisk; Associazione Italiana per la Ricerca sul Cancro; Aalborg Universitet; Rigshospitalet; Kræftens Bekæmpelse; University of Melbourne; University of New South Wales; National Medical Research Council; Universiteit Leiden; Cancer Council NSW; National Cancer Centre of Singapore; Universiteit van Amsterdam; Universitair Medisch Centrum Groningen; Newcastle University; Health and Care Research Wales; KWF Kankerbestrijding; Cancer Research UK; Canadian Institutes of Health Research; Sigrid Juséliuksen Säätiö; University of Southampton; Amsterdam University Medical Centers; Institut National de la Santé et de la Recherche Médicale; Cancer Council Tasmania; Cedars-Sinai Medical Center; Swedish Cancer Foundation; University Hospitals of Leicester NHS Trust; Parc Geneteg Cymru; Svenska Läkaresällskapet; Gentofte Hospital; Deutsche Forschungsgemeinschaft; Medical Research Council; Nordea-fonden; National Institute for Health and Care Research; Odense Universitetshospital; Nebraska Department of Health and Human Services; Comprehensive Cancer Center, City of Hope; Kreftforeningen; South African Medical Research Council; Deutsches Krebsforschungszentrum; Academy of Finland; Suomen Lääketieteen Säätiö; University of Washington; Helsingin Yliopisto; Royal Adelaide Hospital; NIHR Maudsley Biomedical Research Centre; Rijksuniversiteit Groningen; U.S. Department of Health and Human Services; Creighton University; Instituto de Salud Carlos III; Ohio State University","keywords":"Colorectal cancer; Retrospective cohort study; Variation (astronomy); Lynch syndrome; Medicine; Cohort; Oncology; Cancer; Internal medicine; Demography; DNA mismatch repair; Sociology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001431318,0.0004649371,0.0005712735,0.001406431,0.001075896,0.0007078575,0.0005190193,0.0005993342,0.001258349],"category_scores_gemma":[0.002862805,0.0007583004,0.0007932376,0.002005443,0.0004287176,0.0005382049,0.0007050339,0.0006630661,0.0002616165],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006183871,"about_ca_system_score_gemma":0.000714766,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.023698,"about_ca_topic_score_gemma":0.01915138,"domain_scores_codex":[0.9986198,0.0003089877,0.0001371919,0.0005528746,0.0001939193,0.0001872633],"domain_scores_gemma":[0.9977974,0.0003739767,0.0007410966,0.0004955367,0.0002654172,0.0003267414],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001046591,0.00003016674,0.9983343,0.000009029657,0.000112448,0.0003353871,0.0001620966,0.00004489009,0.0002288909,0.00001805486,0.00009290635,0.0005269953],"study_design_scores_gemma":[0.00001829407,0.0001941905,0.9975758,0.00001266291,0.0001024789,0.00123908,0.0003228008,0.0001443886,0.00006198076,0.00001804942,0.0002999701,0.0000103954],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986399,0.0002197002,0.0001995323,0.00001836982,0.000004531879,0.00002896097,0.0007108627,0.000005611788,0.0001725794],"genre_scores_gemma":[0.9987769,0.0001723427,0.0002208766,0.00002515352,0.000004920011,0.00003124218,0.0006656679,0.000003822205,0.00009913596],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.023698,"threshold_uncertainty_score":0.04712015,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01803442414552895,"score_gpt":0.3129280167373696,"score_spread":0.2948935925918407,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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