{"id":"W3166459118","doi":"10.1007/s00044-021-02735-4","title":"Synthesis, structural characterization and antimycobacterial evaluation of several halogenated non-nitro benzothiazinones","year":2021,"lang":"en","type":"article","venue":"Medicinal Chemistry Research","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Deutsches Elektronen-Synchrotron; Deutsche Forschungsgemeinschaft","keywords":"Antimycobacterial; Chemistry; Nitro; Mycobacterium tuberculosis; Stereochemistry; In vitro; Combinatorial chemistry; Mycobacterium; Tuberculosis; Bacteria; Biochemistry; Biology; Organic chemistry; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009636484,0.0001103383,0.0001615121,0.00002859534,0.00009300341,0.00002444465,0.0001106136,0.0001517542,0.0002519421],"category_scores_gemma":[0.0002693655,0.0001057597,0.00003652732,0.0001375097,0.0001382583,0.000004904809,0.0001093687,0.000141195,8.158605e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000321913,"about_ca_system_score_gemma":0.0004196303,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002098597,"about_ca_topic_score_gemma":0.000006804923,"domain_scores_codex":[0.9984803,0.0001398382,0.0001923457,0.0003182186,0.0006315124,0.0002377939],"domain_scores_gemma":[0.9986701,0.00002322107,0.00006310835,0.0002460155,0.000908539,0.00008901222],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001658753,0.00002117695,0.0002990697,0.0001068764,0.00005384002,0.000005389811,0.00005462615,0.000002998664,0.9926283,0.000006420183,0.00002584165,0.00662958],"study_design_scores_gemma":[0.0007011804,0.00007513485,0.004590814,0.0000544454,0.00004756009,0.00007187065,0.0001249949,0.001099,0.9921737,0.00006731109,0.0008917433,0.0001022314],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984403,0.0005050033,0.0001545145,0.0001581783,0.0001238687,0.0001338063,0.00005505075,0.000003554722,0.0004257059],"genre_scores_gemma":[0.9982021,0.0003118877,0.00005632659,0.0000272209,0.0004783791,0.00002816148,0.0005994706,0.00001516129,0.0002812369],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006527348,"threshold_uncertainty_score":0.4312758,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05100630373761286,"score_gpt":0.3638844842698585,"score_spread":0.3128781805322457,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}