{"id":"W3166591395","doi":"10.1158/2159-8290.cd-20-1656","title":"Discovery and Features of an Alkylating Signature in Colorectal Cancer","year":2021,"lang":"en","type":"article","venue":"Cancer Discovery","topic":"Colorectal Cancer Treatments and Studies","field":"Medicine","cited_by":79,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Human Genome Research Institute; Dana-Farber/Harvard Cancer Center; Gary Bennett Family Fund; National Institutes of Health; Huazhong University of Science and Technology; Stand Up To Cancer; Uehara Memorial Foundation; National Cancer Institute; Entertainment Industry Foundation; Mitsukoshi Health and Welfare Foundation; American Society of Clinical Oncology; American Association for Cancer Research; Japan Society for the Promotion of Science; Cancer Research UK; Conquer Cancer Foundation","keywords":"Signature (topology); Colorectal cancer; Computational biology; Cancer; Biology; Medicine; Bioinformatics; Cancer research; Genetics; Mathematics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004879612,0.0001853036,0.0004627233,0.00006341897,0.00005685566,0.00004755103,0.00004307608,0.00008791014,0.00004319727],"category_scores_gemma":[0.0000398477,0.0001457382,0.0000786474,0.0002708094,0.0001142987,0.0004550532,0.00008087229,0.0002033786,1.497222e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002199049,"about_ca_system_score_gemma":0.0004047731,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001680962,"about_ca_topic_score_gemma":0.01097822,"domain_scores_codex":[0.998948,0.00003253281,0.0002105533,0.0003776344,0.0001973175,0.0002339475],"domain_scores_gemma":[0.9995863,0.00006059958,0.00008153821,0.0001323493,0.00007726892,0.00006190673],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002354502,0.0005814134,0.7306721,0.0006611432,0.0006781691,0.0005211693,0.003672388,0.0002528919,0.1880503,0.0005934579,0.0007920761,0.07117038],"study_design_scores_gemma":[0.001991232,0.000290054,0.9046926,0.0005938782,0.0001706647,0.00002835833,0.001530763,0.00004427955,0.09005956,0.000138061,0.0002628998,0.0001976176],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9477859,0.04903336,0.00000410817,0.0005938003,0.0002755583,0.0002162082,0.0001894618,0.0000136381,0.001888019],"genre_scores_gemma":[0.9937786,0.004206903,0.00007973768,0.0002817257,0.0001975527,0.0001249017,0.00003706874,0.00002121,0.001272236],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1740205,"threshold_uncertainty_score":0.6126108,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0120878616643704,"score_gpt":0.2995960701816546,"score_spread":0.2875082085172842,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}