{"id":"W3166591395","doi":"10.1158/2159-8290.cd-20-1656","title":"Discovery and Features of an Alkylating Signature in Colorectal Cancer","year":2021,"lang":"en","type":"article","venue":"Cancer Discovery","topic":"Colorectal Cancer Treatments and Studies","field":"Medicine","cited_by":79,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Human Genome Research Institute; Dana-Farber/Harvard Cancer Center; Gary Bennett Family Fund; National Institutes of Health; Huazhong University of Science and Technology; Stand Up To Cancer; Uehara Memorial Foundation; National Cancer Institute; Entertainment Industry Foundation; Mitsukoshi Health and Welfare Foundation; American Society of Clinical Oncology; American Association for Cancer Research; Japan Society for the Promotion of Science; Cancer Research UK; Conquer Cancer Foundation","keywords":"Signature (topology); Colorectal cancer; Computational biology; Cancer; Biology; Medicine; Bioinformatics; Cancer research; Genetics; Mathematics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002674035,0.0001520226,0.0002162354,0.000955147,0.0002151046,0.0004537414,0.0001333918,0.0002929709,0.00133174],"category_scores_gemma":[0.0008164595,0.0001122006,0.000231171,0.001079425,0.0001860527,0.0001349959,0.0003017647,0.0002515333,0.0002380823],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001963103,"about_ca_system_score_gemma":0.0001760441,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001465273,"about_ca_topic_score_gemma":0.003978935,"domain_scores_codex":[0.999821,0.00002292176,0.00001908745,0.00006798952,0.00004772988,0.0000214073],"domain_scores_gemma":[0.9992076,0.0001493988,0.0003964973,0.00006547514,0.000108937,0.00007207227],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007421374,0.00006289867,0.8099969,0.000360031,0.0003666659,0.001191615,0.0001369554,0.0004737047,0.1446026,0.0003288959,0.001257508,0.04048015],"study_design_scores_gemma":[0.00001391942,0.0001322798,0.9718014,0.00004076805,0.0002159437,0.002921923,0.00008480001,0.0008879429,0.01821628,0.0003456949,0.005324981,0.00001416105],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906661,0.002476664,0.001513314,0.0002385881,0.00002021524,0.00001718693,0.003672711,0.00006298509,0.001332239],"genre_scores_gemma":[0.9958724,0.0005204197,0.001205435,0.0001199761,0.00001631339,0.000005478389,0.00181953,0.00001232621,0.0004282309],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001465273,"threshold_uncertainty_score":0.004455149,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0120878616643704,"score_gpt":0.2995960701816546,"score_spread":0.2875082085172842,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}