{"id":"W3166680572","doi":"10.1093/neuonc/noab090.103","title":"HGG-39. ALTERNATIVE SPLICING OF <i>NEUROFIBROMIN 1</i> IS ASSOCIATED WITH ELEVATED MAPK ACTIVITY AND POOR PROGNOSIS IN HIGH-GRADE GLIOMA","year":2021,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; Hospital for Sick Children","funders":"","keywords":"Neurofibromin 1; RNA splicing; MAPK/ERK pathway; Biology; Cancer research; Spliceosome; Carcinogenesis; Alternative splicing; Genetics; Gene; Signal transduction; RNA; Messenger RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001186446,0.0001770741,0.0001464092,0.000317795,0.0002089512,0.0002595155,0.0001090344,0.0001832793,0.001239505],"category_scores_gemma":[0.0002560511,0.0000798484,0.0001402371,0.0003244464,0.0001820383,0.00008610429,0.0001708215,0.000216993,0.0002305129],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001418652,"about_ca_system_score_gemma":0.0001257671,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009130613,"about_ca_topic_score_gemma":0.001450794,"domain_scores_codex":[0.999907,0.00001209183,0.00000756044,0.00003205873,0.00002214859,0.00001915836],"domain_scores_gemma":[0.9997559,0.00002744775,0.0001268947,0.00001417906,0.000017559,0.00005804098],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000808625,0.0000440356,0.8760667,0.00004747296,0.00009489545,0.001450466,0.0001127564,0.0001167729,0.1121123,0.00008959058,0.0004334995,0.00862278],"study_design_scores_gemma":[0.000006546577,0.0001150434,0.9892021,0.000005826378,0.00003285363,0.003454952,0.00009664446,0.0002481847,0.00611555,0.00008826861,0.0006303841,0.000003540836],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992835,0.0001124077,0.000134842,0.00001700356,0.000001898034,0.00000324001,0.0002627614,0.000007767178,0.0001765389],"genre_scores_gemma":[0.9993379,0.00005357574,0.0001472751,0.00001314624,0.000003128342,0.000003046638,0.0003211839,0.000004668031,0.0001161177],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001239505,"threshold_uncertainty_score":0.004146576,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02046621187366391,"score_gpt":0.2823634488948709,"score_spread":0.261897237021207,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}