{"id":"W3166692373","doi":"10.7554/elife.65234.sa2","title":"Author response: A non-genetic, cell cycle-dependent mechanism of platinum resistance in lung adenocarcinoma","year":2021,"lang":"en","type":"peer-review","venue":"","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Research Institute in Oncology and Hematology; CancerCare Manitoba","funders":"","keywords":"Cisplatin; Adenocarcinoma; Cancer research; Lung cancer; DNA damage; Senescence; Cancer; Biology; In vivo; Cell cycle; Chemotherapy; Bioinformatics; Medicine; Oncology; Genetics; DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005427116,0.0005327922,0.0008284765,0.001140534,0.001368564,0.003413674,0.001318297,0.00625937,0.1247372],"category_scores_gemma":[0.06153111,0.0003270379,0.0005696086,0.0007546318,0.001104598,0.002052717,0.001868534,0.00501432,0.06777015],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00200397,"about_ca_system_score_gemma":0.004848809,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002082182,"about_ca_topic_score_gemma":0.005201451,"domain_scores_codex":[0.994105,0.00119867,0.0004735725,0.0006088387,0.003173758,0.0004401724],"domain_scores_gemma":[0.9475278,0.0100175,0.001834317,0.001567822,0.03425839,0.004794161],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007096622,0.00001056272,0.0002254392,0.0002965435,0.000009940917,0.0002274432,0.00006938208,0.00005055593,0.000341883,0.0003637553,0.9827199,0.01561375],"study_design_scores_gemma":[0.00003437202,0.00003858898,0.0009169528,0.0002179773,0.00001299368,0.0004097233,0.0002482189,0.00009746987,0.000585267,0.0007365619,0.9966786,0.00002328111],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"other","genre_scores_codex":[0.002171616,0.006196172,0.001334559,0.5978804,0.3575779,0.0002545937,0.001507284,0.0006551164,0.03242231],"genre_scores_gemma":[0.02509017,0.01439239,0.002142721,0.218883,0.126963,0.0002133441,0.001823538,0.001032532,0.6094592],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.1247372,"threshold_uncertainty_score":0.4172876,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01205839596186319,"score_gpt":0.2736888696527315,"score_spread":0.2616304736908683,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}