{"id":"W3166711975","doi":"10.1200/jco.2021.39.15_suppl.2612","title":"First-in-human, phase I study of PF-06753512, a vaccine-based immunotherapy regimen (PrCa VBIR), in biochemical relapse (BCR) and metastatic castration-resistant prostate cancer (mCRPC).","year":2021,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Pfizer","keywords":"Medicine; Prostate cancer; Antigen; Internal medicine; Prostate-specific antigen; Immunotherapy; Regimen; Oncology; Immunology; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001377497,0.001744895,0.001638909,0.0005287288,0.0005224775,0.001093891,0.001193217,0.001161388,0.00383013],"category_scores_gemma":[0.0005285907,0.0006986095,0.001036037,0.000403266,0.001283544,0.0008985063,0.0003697669,0.003872392,0.00121319],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001141124,"about_ca_system_score_gemma":0.002085953,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001972841,"about_ca_topic_score_gemma":0.003744597,"domain_scores_codex":[0.9994554,0.0001562945,0.00001915031,0.000105785,0.0000477406,0.0002156188],"domain_scores_gemma":[0.99945,0.0000509784,0.00006998463,0.00005574757,0.00003064648,0.0003427014],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.3623627,0.2916777,0.006564456,0.001068892,0.0009884218,0.0006046621,0.0006133673,0.004799319,0.1751048,0.0006540451,0.009482716,0.1460789],"study_design_scores_gemma":[0.1534421,0.8176515,0.007420891,0.00002656911,0.0002741343,0.0004794489,0.0000566672,0.0009570784,0.0149074,0.0001712499,0.004583566,0.00002938653],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9862058,0.002210802,0.00122528,0.000402486,0.0001904172,0.005104994,0.001666092,0.000253299,0.002740794],"genre_scores_gemma":[0.987449,0.001287002,0.001864778,0.0005617422,0.0001431442,0.002238446,0.002288852,0.00004407271,0.004122927],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00383013,"threshold_uncertainty_score":0.01281309,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05778106570875469,"score_gpt":0.4243905280793919,"score_spread":0.3666094623706372,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}