{"id":"W3166741510","doi":"10.1200/jco.2021.39.15_suppl.tps9587","title":"CAcTUS: A parallel arm, biomarker driven, phase II feasibility trial to determine the role of circulating tumor DNA in guiding a switch between targeted therapy and immune therapy in patients with advanced cutaneous melanoma.","year":2021,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Bristol-Myers Squibb Canada","keywords":"Medicine; Immunotherapy; Melanoma; Oncology; Biomarker; Clinical endpoint; Liquid biopsy; Targeted therapy; Phases of clinical research; Clinical trial; Internal medicine; Cancer research; Cancer; Immunology; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001488357,0.001496539,0.001386156,0.0006942698,0.0003189155,0.0009186657,0.001210847,0.001806751,0.00816528],"category_scores_gemma":[0.001610357,0.0003951043,0.000822252,0.0004020099,0.00127422,0.00109571,0.0004875996,0.002760678,0.001229191],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001131509,"about_ca_system_score_gemma":0.001235187,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007830745,"about_ca_topic_score_gemma":0.001245633,"domain_scores_codex":[0.9995278,0.000215397,0.00002010768,0.00008035153,0.00005282579,0.0001035262],"domain_scores_gemma":[0.9989605,0.0001989447,0.0002757584,0.0001053895,0.00006256522,0.0003968116],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8862466,0.03165444,0.007149594,0.000508954,0.0004343049,0.0002228134,0.000168121,0.001544748,0.01434603,0.0003754837,0.002481116,0.05486768],"study_design_scores_gemma":[0.6231413,0.3638437,0.008372752,0.00003077984,0.0001562158,0.0001991935,0.00003930687,0.0009396136,0.001403375,0.000239767,0.001614835,0.00001901043],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908205,0.001150833,0.0003979351,0.0005764769,0.0002063547,0.003933846,0.0007529781,0.0001374246,0.00202361],"genre_scores_gemma":[0.9823942,0.0007908051,0.002159059,0.001375942,0.0004648613,0.007084309,0.002100806,0.00003574238,0.003594409],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00816528,"threshold_uncertainty_score":0.02731556,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0664869218459965,"score_gpt":0.3820331397867959,"score_spread":0.3155462179407994,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}