{"id":"W3166746419","doi":"10.1200/jco.2021.39.15_suppl.e15038","title":"Preliminary results of BEAVER: An investigator-initiated phase II study of binimetinib and encorafenib for the treatment of advanced solid tumors with non-V600E BRAF mutations (mts).","year":2021,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Colorectal Cancer Treatments and Studies","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; University of Toronto; Jewish General Hospital","funders":"Pfizer; Conquer Cancer Foundation","keywords":"Medicine; Internal medicine; Melanoma; Oncology; Adverse effect; Cancer research","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001329883,0.00115067,0.0009478178,0.0004180675,0.0003484252,0.0008977674,0.0008042101,0.0009592985,0.00667572],"category_scores_gemma":[0.001125886,0.0002972021,0.0006257628,0.0003051749,0.0004700482,0.0007135488,0.0005316287,0.00197746,0.001163921],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006472458,"about_ca_system_score_gemma":0.001549276,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001705487,"about_ca_topic_score_gemma":0.005747837,"domain_scores_codex":[0.999612,0.0001656914,0.00001900159,0.0000438179,0.00005902251,0.000100512],"domain_scores_gemma":[0.9993355,0.0001285041,0.00008729043,0.00003163154,0.00004911557,0.0003679451],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5147035,0.07445458,0.02023575,0.002000236,0.001892359,0.003331298,0.0009422236,0.007357635,0.0676356,0.001776595,0.04698087,0.2586894],"study_design_scores_gemma":[0.3638305,0.5307509,0.04276819,0.0001434723,0.000913303,0.002410844,0.000159944,0.003241475,0.01289012,0.0009230744,0.04188104,0.0000871809],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9682792,0.003407354,0.001479935,0.001605889,0.0001940634,0.004538664,0.005440499,0.0002897009,0.01476467],"genre_scores_gemma":[0.9562938,0.002848508,0.00346044,0.001818476,0.0001604933,0.003026243,0.01272315,0.00007870623,0.01959035],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00667572,"threshold_uncertainty_score":0.02233249,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.149840541080638,"score_gpt":0.4920796621493703,"score_spread":0.3422391210687322,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}