{"id":"W3166794517","doi":"10.1073/pnas.2022115118","title":"Chemical and genetic rescue of in vivo progranulin-deficient lysosomal and autophagic defects.","year":2021,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Centre Hospitalier de l’Université de Montréal; Université de Montréal; McGill University Health Centre","funders":"National Institutes of Health","keywords":"Neurodegeneration; Biology; Autophagy; Frontotemporal dementia; Phenotype; Genetic screen; Neuroscience; Computational biology; Mutation; Model organism; Disease; Genetics; Gene; Dementia; Medicine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001242099,0.0004086518,0.0001753596,0.000389087,0.0002130407,0.0001700014,0.0002501839,0.0003625083,0.00171873],"category_scores_gemma":[0.0001145152,0.0001357067,0.000250103,0.0001184701,0.0003344437,0.0001137795,0.0002068753,0.0005126108,0.0004342476],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000372767,"about_ca_system_score_gemma":0.0004201691,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001451339,"about_ca_topic_score_gemma":0.002430082,"domain_scores_codex":[0.999894,0.00001785674,0.00001061414,0.00001727348,0.00003244565,0.00002775628],"domain_scores_gemma":[0.9998949,0.00001709829,0.00003205745,0.00001450606,0.000008554244,0.00003282193],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009998748,0.00005471447,0.00006052356,0.00005315392,0.000009903397,0.000208035,0.000007273227,0.0001625476,0.9975739,0.0002519512,0.0000852973,0.001432709],"study_design_scores_gemma":[0.00004611187,0.0003606345,0.001481254,0.0000147321,0.00002416526,0.0007806304,0.00001752609,0.000559504,0.9928319,0.0001024785,0.003774729,0.00000623704],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9844583,0.00366665,0.002790351,0.0003353741,0.0001468158,0.0001039097,0.001245397,0.0002101233,0.00704303],"genre_scores_gemma":[0.9840848,0.001812997,0.004317145,0.00008481172,0.00001259664,0.00008091787,0.00096254,0.00004131718,0.008602938],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00171873,"threshold_uncertainty_score":0.005749702,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03876642638609647,"score_gpt":0.31970427623795,"score_spread":0.2809378498518535,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}