{"id":"W3166806880","doi":"10.1200/jco.2021.39.15_suppl.7006","title":"Effect of olutasidenib (FT-2102) on complete remissions in patients with relapsed/refractory (R/R) m<i>IDH1</i> acute myeloid leukemia (AML): Results from a planned interim analysis of a phase 2 clinical trial.","year":2021,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Internal medicine; Tolerability; Gastroenterology; Myeloid leukemia; Refractory (planetary science); Interim analysis; Clinical endpoint; Surrogate endpoint; Cytarabine; Clinical trial; Surgery; Adverse effect","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001246889,0.0007247042,0.001157668,0.0003241823,0.0002159058,0.0004998899,0.0004565722,0.0005499678,0.002308923],"category_scores_gemma":[0.0007003223,0.0002450109,0.0008808337,0.0002747198,0.0003816565,0.0004903934,0.0002789728,0.001515905,0.000443538],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005047575,"about_ca_system_score_gemma":0.0007650906,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005516509,"about_ca_topic_score_gemma":0.00176996,"domain_scores_codex":[0.9997128,0.0001482131,0.00001824537,0.0000376941,0.00002705547,0.00005605436],"domain_scores_gemma":[0.9995388,0.00009388166,0.0001275125,0.00004041653,0.00001747865,0.0001819454],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7505477,0.02135431,0.009949414,0.0007458269,0.001605413,0.0002733372,0.0001913188,0.002483098,0.04074089,0.0002023599,0.003709496,0.1681968],"study_design_scores_gemma":[0.3917006,0.5480122,0.04545449,0.00006334557,0.0009533768,0.0006020523,0.00006126275,0.001114579,0.007725616,0.0002419065,0.00403369,0.0000369122],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943835,0.002063475,0.0002775092,0.0002147765,0.00004698881,0.0005463447,0.001012711,0.00008279592,0.001372015],"genre_scores_gemma":[0.9945025,0.0011153,0.0005935574,0.0003292656,0.00008914882,0.0004320926,0.00186081,0.00001699043,0.001060277],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002308923,"threshold_uncertainty_score":0.007724166,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1096817984911184,"score_gpt":0.4842132280598578,"score_spread":0.3745314295687394,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}