{"id":"W3166831684","doi":"10.1128/jvi.00471-21","title":"HIV-1 Nef Induces Hck/Lyn-Dependent Expansion of Myeloid-Derived Suppressor Cells Associated with Elevated Interleukin-17/G-CSF Levels","year":2021,"lang":"en","type":"article","venue":"Journal of Virology","topic":"Immune cells in cancer","field":"Immunology and Microbiology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université de Montréal; Montreal Clinical Research Institute","funders":"Canadian Institutes of Health Research; National Heart and Lung Institute; Government of Canada","keywords":"CD11c; Biology; Myeloid; LYN; Integrin alpha M; Myeloid-derived Suppressor Cell; CD14; Dendritic cell; Spleen; Immunology; T cell; Molecular biology; Cancer research; Cell biology; Flow cytometry; Immune system; Signal transduction; Proto-oncogene tyrosine-protein kinase Src; Suppressor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000111185,0.0002226007,0.0001525573,0.0002388644,0.00009499295,0.0002350778,0.00008596114,0.000176974,0.00173656],"category_scores_gemma":[0.00009378229,0.00007255898,0.0001440924,0.00007243461,0.0001927855,0.00008380866,0.0001672761,0.0005268076,0.0003857231],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001913523,"about_ca_system_score_gemma":0.000120689,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000280212,"about_ca_topic_score_gemma":0.0004948961,"domain_scores_codex":[0.9998779,0.00002312975,0.000008373366,0.00001466354,0.000025777,0.0000501991],"domain_scores_gemma":[0.9998857,0.00003068815,0.00001662688,0.00001903979,0.000007866185,0.00004008846],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008187336,0.00003325912,0.0002243385,0.00001281456,0.000002174012,0.00008959689,0.00001247964,0.0000241662,0.9984645,0.0000981234,0.00004103829,0.000915754],"study_design_scores_gemma":[0.00002323354,0.0002664568,0.004938576,0.000003677774,0.000007197264,0.0004659437,0.00002393414,0.0006827028,0.9915547,0.00006499195,0.001966383,0.00000215856],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969049,0.0005122944,0.0007818287,0.00004655479,0.00002272139,0.00002335659,0.0003330446,0.00005955016,0.001315777],"genre_scores_gemma":[0.9966053,0.0001847086,0.0009044089,0.00002881039,0.00001017677,0.00002507129,0.0003812592,0.0000145473,0.001845646],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00173656,"threshold_uncertainty_score":0.005809367,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01652049491530192,"score_gpt":0.2391319636123742,"score_spread":0.2226114686970723,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}