{"id":"W3166849541","doi":"10.1016/j.celrep.2021.109226","title":"Nucleocytoplasmic transport of the RNA-binding protein CELF2 regulates neural stem cell fates","year":2021,"lang":"en","type":"article","venue":"Cell Reports","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital; University of Calgary; University of Alberta","funders":"Canadian Institutes of Health Research; Cumming School of Medicine, University of Calgary; Azrieli Foundation; Mitacs","keywords":"Cell fate determination; Neural stem cell; Biology; Cell biology; RNA-binding protein; Progenitor cell; RNA; Stem cell; Neurogenesis; Translation (biology); Cellular differentiation; Regulation of gene expression; Gene; Messenger RNA; Transcription factor; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001916645,0.0001364118,0.0001640296,0.00002270877,0.0001029634,0.00001822278,0.0001478832,0.0001118738,0.00003029515],"category_scores_gemma":[0.00001826135,0.0001047188,0.0001771151,0.0001255013,0.00007097636,0.000004717081,0.0000971866,0.0001302098,0.000002017872],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000128498,"about_ca_system_score_gemma":0.0001679829,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002615691,"about_ca_topic_score_gemma":0.00002012913,"domain_scores_codex":[0.9987136,0.00005617883,0.000342422,0.0003622651,0.0002324019,0.0002931271],"domain_scores_gemma":[0.9990128,0.000007694154,0.0001950047,0.0005921976,0.0001062126,0.00008614141],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000176318,0.00004808995,0.009502277,0.00009757913,0.00001247263,0.0002632457,0.00003490627,0.00008413708,0.9893863,0.000002393775,0.0001882671,0.0003626587],"study_design_scores_gemma":[0.0001674356,0.00005717572,0.001477113,0.00003239673,0.00001211095,0.0001077398,0.0001395446,0.00004694007,0.9959743,0.00001286826,0.001853877,0.0001185126],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955864,0.0006019537,0.00001505518,0.00006689689,0.0001270381,0.0002379406,0.000005142824,0.000009323637,0.003350262],"genre_scores_gemma":[0.9655636,0.0000363718,0.00009860255,0.00002043707,0.00004797519,0.00001195321,0.00003091095,0.00002402522,0.03416615],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03081589,"threshold_uncertainty_score":0.427031,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009062884394943611,"score_gpt":0.218787910244273,"score_spread":0.2097250258493294,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}