{"id":"W3166904740","doi":"10.1096/fasebj.27.1_supplement.912.2","title":"Mechanoprotection by Polycystins Against Apoptosis is Mediated Through the Opening of Stretch‐Activated K2P Channels","year":2013,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Genetic and Kidney Cyst Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; McGill University","funders":"","keywords":"PKD1; Autosomal dominant polycystic kidney disease; Mechanotransduction; Apoptosis; Polycystic kidney disease; Cell biology; Kidney; Chemistry; HEK 293 cells; Biology; Gene; Endocrinology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002423615,0.0002755475,0.0003633174,0.0002095919,0.0001805067,0.0004244705,0.0001515089,0.0004457201,0.001472294],"category_scores_gemma":[0.0002578689,0.00009405348,0.0003375669,0.0001135594,0.000325795,0.0003831972,0.0004211212,0.0005118328,0.0002769917],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001681167,"about_ca_system_score_gemma":0.0001759448,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001424986,"about_ca_topic_score_gemma":0.000184236,"domain_scores_codex":[0.9997203,0.00006005105,0.00003156692,0.00003847936,0.00008616055,0.00006341543],"domain_scores_gemma":[0.9998009,0.00002764444,0.00006932666,0.00002605322,0.00003373016,0.00004235053],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002263586,0.00004599824,0.0004715256,0.0001488484,0.00001754835,0.0001227769,0.00002456564,0.00006385249,0.9948034,0.0001613438,0.0001226019,0.003791208],"study_design_scores_gemma":[0.00009180298,0.001830063,0.04735763,0.00004983678,0.00004836358,0.00134648,0.0001538977,0.001219136,0.9386682,0.0005164846,0.00869851,0.00001968482],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9825653,0.009402815,0.004300969,0.0005489446,0.000160975,0.00004600502,0.0002448864,0.0001484337,0.002581697],"genre_scores_gemma":[0.9947778,0.002456642,0.001282569,0.0001485521,0.00003425018,0.00004263642,0.000153115,0.00000973644,0.001094695],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001472294,"threshold_uncertainty_score":0.004925311,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009665247440666243,"score_gpt":0.2233057265625261,"score_spread":0.2136404791218598,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}