{"id":"W3166940707","doi":"10.1093/neuonc/noab090.168","title":"RARE-07. EFFICACY AND SAFETY OF LAROTRECTINIB IN PEDIATRIC PATIENTS WITH TROPOMYOSIN RECEPTOR KINASE (TRK) FUSION-POSITIVE PRIMARY CENTRAL NERVOUS SYSTEM (CNS) TUMORS","year":2021,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine","funders":"","keywords":"Trk receptor; Medicine; Internal medicine; Glioma; Oncology; Neuroblastoma; Gastroenterology; Cancer research; Receptor; Neurotrophin; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005440774,0.0002460151,0.0007992127,0.0002335793,0.0001338664,0.0004747275,0.0002363507,0.0003047228,0.003054944],"category_scores_gemma":[0.0006724967,0.0001381234,0.0006232816,0.00034499,0.0002322655,0.0002748257,0.0002270765,0.0007184001,0.000815331],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007414398,"about_ca_system_score_gemma":0.0008842435,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009235739,"about_ca_topic_score_gemma":0.002448199,"domain_scores_codex":[0.9997541,0.00008034029,0.00002516431,0.000042556,0.00005461351,0.00004327211],"domain_scores_gemma":[0.999531,0.00009491296,0.0001633544,0.00002154537,0.00005727525,0.000131893],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.1102626,0.004422449,0.1636105,0.003272086,0.00165962,0.003558964,0.0003866047,0.006358947,0.06870095,0.001552969,0.03558154,0.6006328],"study_design_scores_gemma":[0.0963834,0.2133061,0.4670155,0.001098098,0.004358662,0.02367927,0.0005245123,0.01321717,0.05457067,0.001260751,0.1244446,0.0001412141],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9686981,0.01322262,0.0008840563,0.0006501884,0.00009304183,0.0004280912,0.006172464,0.000270981,0.009580356],"genre_scores_gemma":[0.9829044,0.004848167,0.002262019,0.0006896334,0.0001028728,0.0004672704,0.007271723,0.00004002951,0.001413851],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003054944,"threshold_uncertainty_score":0.01021981,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006823661440236482,"score_gpt":0.2321180939236678,"score_spread":0.2252944324834313,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}