{"id":"W3166956606","doi":"10.3390/ph14060531","title":"PESIN Conjugates for Multimodal Imaging: Can Multimerization Compensate Charge Influences on Cell Binding Properties? A Case Study","year":2021,"lang":"en","type":"article","venue":"Pharmaceuticals","topic":"Radiopharmaceutical Chemistry and Applications","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Ludwig-Maximilians-Universität München; Paul Scherrer Institut; Deutsche Forschungsgemeinschaft","keywords":"Homotetramer; Peptide; Chemistry; Receptor; Affinities; Fluorescence; Biophysics; Ligand (biochemistry); In vitro; Conjugate; Combinatorial chemistry; Stereochemistry; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002541967,0.0002668359,0.0003729325,0.00005873608,0.0003334211,0.00009243232,0.00009989972,0.00005701949,0.000288772],"category_scores_gemma":[0.0002135689,0.0002310793,0.0001124777,0.0002846311,0.0001378972,0.00008388831,0.00004621272,0.0003066653,0.00007721269],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007749781,"about_ca_system_score_gemma":0.0001369896,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002313482,"about_ca_topic_score_gemma":0.000001220021,"domain_scores_codex":[0.99821,0.00009225406,0.0004373224,0.0005611659,0.0002581623,0.0004411406],"domain_scores_gemma":[0.9986757,0.0002655041,0.0000932813,0.0002863313,0.0002665069,0.0004126942],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002575214,0.002174308,0.01478311,0.0003226991,0.00009960245,0.001194323,0.000674161,0.00004391366,0.9783484,0.00004511459,0.0001398958,0.001916947],"study_design_scores_gemma":[0.005077108,0.00009412535,0.0002369857,0.00007026806,0.0004288812,0.0007892398,0.001421253,0.0444179,0.9424733,0.000007602434,0.004698846,0.0002844733],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934279,0.0002942016,0.0001242719,0.003293633,0.00009367962,0.001858519,0.00009910591,0.0001386831,0.0006699555],"genre_scores_gemma":[0.9961344,0.00002457036,0.0006757343,0.001823446,0.0001899611,0.0004604859,0.00008173809,0.00004106436,0.0005685831],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04437399,"threshold_uncertainty_score":0.9423141,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1042562955716451,"score_gpt":0.402311893518334,"score_spread":0.2980555979466889,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}