{"id":"W3166963116","doi":"10.1038/s41467-021-23496-z","title":"Structure and mechanism of the human NHE1-CHP1 complex","year":2021,"lang":"en","type":"article","venue":"Nature Communications","topic":"Signaling Pathways in Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":98,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research; Chinese Academy of Sciences; Institute of Biophysics, Chinese Academy of Sciences; National Natural Science Foundation of China; McGill University","keywords":"Chemistry; Intracellular pH; Transporter; Protein subunit; Biophysics; Conformational change; Cell biology; Intracellular; Biochemistry; Biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004791636,0.00006394041,0.00006571916,0.000008258257,0.0001858395,0.00001017732,0.0005824458,0.0001700414,0.00002025156],"category_scores_gemma":[0.0001424088,0.00005225898,0.00004938128,0.00008641277,0.0001403579,0.000001137048,0.000663858,0.000247665,2.711071e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004561803,"about_ca_system_score_gemma":0.00005489837,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002939117,"about_ca_topic_score_gemma":0.0001269839,"domain_scores_codex":[0.9995319,0.0001100979,0.00009841424,0.000120949,0.00007433099,0.00006434213],"domain_scores_gemma":[0.9981662,0.00002074137,0.00005949275,0.001587156,0.0001378896,0.00002853786],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000001404699,0.00002894164,0.002071572,0.000006446423,0.00002518419,1.818172e-7,0.00003190241,0.000002165657,0.9575927,0.03864612,0.001510165,0.00008325319],"study_design_scores_gemma":[0.0002349043,0.00001486128,0.01966899,0.00001570904,0.00003830952,0.00001412736,0.00006361189,0.00002919012,0.949648,0.005265251,0.02490835,0.00009870286],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9883044,0.007739914,0.00006017193,0.001900931,0.00009299655,0.0001178427,0.0002062127,0.000009634115,0.001567865],"genre_scores_gemma":[0.9967224,0.00007884816,0.002219015,0.0005725063,0.00002965782,0.000004392014,0.0002589475,0.000009056097,0.0001051977],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03338087,"threshold_uncertainty_score":0.2131059,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02466801671749536,"score_gpt":0.3074635574582454,"score_spread":0.2827955407407501,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}