{"id":"W3166963116","doi":"10.1038/s41467-021-23496-z","title":"Structure and mechanism of the human NHE1-CHP1 complex","year":2021,"lang":"en","type":"article","venue":"Nature Communications","topic":"Signaling Pathways in Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":98,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research; Chinese Academy of Sciences; Institute of Biophysics, Chinese Academy of Sciences; National Natural Science Foundation of China; McGill University","keywords":"Chemistry; Intracellular pH; Transporter; Protein subunit; Biophysics; Conformational change; Cell biology; Intracellular; Biochemistry; Biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008554532,0.0002079618,0.0001807461,0.0001663903,0.0003748456,0.0003626654,0.000426667,0.0004712523,0.001755181],"category_scores_gemma":[0.0001644989,0.000206591,0.0001858233,0.0001505872,0.0002257827,0.0003475373,0.0002442847,0.0004578095,0.0005446199],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008200008,"about_ca_system_score_gemma":0.0002023433,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001391622,"about_ca_topic_score_gemma":0.0009156011,"domain_scores_codex":[0.9999189,0.000008092305,0.000003682983,0.0000375937,0.00001676321,0.00001490081],"domain_scores_gemma":[0.9999422,0.000006730668,0.00001785855,0.000007081727,0.000007927467,0.00001818844],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006398697,0.00007050663,0.002091425,0.0002450114,0.0000421535,0.0005703496,0.0002387382,0.001677827,0.9819078,0.003323898,0.001468266,0.007724046],"study_design_scores_gemma":[0.0001577862,0.0003897359,0.04415372,0.0000745768,0.00008271937,0.003034563,0.0002409978,0.02627184,0.8832582,0.002516616,0.03975236,0.00006677936],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9825591,0.006498949,0.005274755,0.001026031,0.00004440489,0.00004113452,0.0006897367,0.000157696,0.003708259],"genre_scores_gemma":[0.9904129,0.001646626,0.002982779,0.0002080837,0.00002000585,0.00002583932,0.001891622,0.00001957625,0.002792579],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001755181,"threshold_uncertainty_score":0.005949497,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02466801671749536,"score_gpt":0.3074635574582454,"score_spread":0.2827955407407501,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}