{"id":"W3167068736","doi":"10.1038/s41467-021-23620-z","title":"A multicentre validation study of the diagnostic value of plasma neurofilament light","year":2021,"lang":"en","type":"article","venue":"Nature Communications","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":555,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"Sanofi Genzyme; Horizon 2020 Framework Programme; National Institutes of Health; Medical Research Council; Demensfonden; UK Dementia Research Institute; Mitsubishi Tanabe Pharma Corporation; Economic and Social Research Council; Skånes universitetssjukhus; Alzheimerfonden; Göteborgs Universitet; Knut och Alice Wallenbergs Stiftelse; European Commission; Hjärnfonden; King's College London; Lunds Universitet; Marcus och Amalia Wallenbergs minnesfond; Stiftelsen för Strategisk Forskning; National Institute on Aging; National Institute for Health and Care Research; Alexion Pharmaceuticals; Torsten Söderbergs Stiftelse; Apellis Pharmaceuticals; Cytokinetics; Vetenskapsrådet; Parkinsonfonden; Kommunfullmäktige, Stockholms Stad; Agence Nationale de la Recherche; Australian Government; EU Joint Programme – Neurodegenerative Disease Research; Wellcome Trust; Avid Radiopharmaceuticals; Parkinson Research Foundation; NIHR Maudsley Biomedical Research Centre; South London and Maudsley NHS Foundation Trust; Sanofi; Eli Lilly and Company; Motor Neurone Disease Association; Biogen","keywords":"Neurodegeneration; Amyotrophic lateral sclerosis; Medicine; Dementia; Parkinsonism; Biomarker; Frontotemporal dementia; Depression (economics); Internal medicine; Pathology; Oncology; Psychiatry; Disease; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001447509,0.00007437573,0.0001798147,0.00004408189,0.000111466,0.00000805067,0.0005481605,0.0001037743,0.00004253549],"category_scores_gemma":[0.002125896,0.00005033412,0.00007485728,0.000513478,0.00007251013,0.00003541513,0.0006069291,0.0006817821,0.000004789491],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005564372,"about_ca_system_score_gemma":0.0001306463,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005400062,"about_ca_topic_score_gemma":0.0001815826,"domain_scores_codex":[0.9985894,0.0004481747,0.0002883373,0.0001306155,0.0004368504,0.0001066248],"domain_scores_gemma":[0.9964413,0.0008104882,0.0001298135,0.002102944,0.0004679151,0.00004753257],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001445677,0.012591,0.6358158,0.0001926958,0.0005271587,0.00001557448,0.008676588,0.0003760927,0.3288801,0.006654582,0.003248351,0.002877539],"study_design_scores_gemma":[0.001451954,0.0001518066,0.9540006,0.0001640696,0.000173156,0.000007854706,0.0007601757,0.0009558555,0.03994584,0.00002416315,0.00231151,0.0000530001],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9839879,0.0007959675,0.000002261237,0.01349334,0.00008380088,0.0007462609,0.00000818271,0.00001212508,0.000870172],"genre_scores_gemma":[0.998575,0.0003630997,0.0006349308,0.0001365976,0.00001643932,0.00003867807,0.00002582033,0.00001116414,0.0001983111],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3181848,"threshold_uncertainty_score":0.2962042,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03151824915561602,"score_gpt":0.340661758102643,"score_spread":0.309143508947027,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}