{"id":"W3167068736","doi":"10.1038/s41467-021-23620-z","title":"A multicentre validation study of the diagnostic value of plasma neurofilament light","year":2021,"lang":"en","type":"article","venue":"Nature Communications","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":555,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"Sanofi Genzyme; Horizon 2020 Framework Programme; National Institutes of Health; Medical Research Council; Demensfonden; UK Dementia Research Institute; Mitsubishi Tanabe Pharma Corporation; Economic and Social Research Council; Skånes universitetssjukhus; Alzheimerfonden; Göteborgs Universitet; Knut och Alice Wallenbergs Stiftelse; European Commission; Hjärnfonden; King's College London; Lunds Universitet; Marcus och Amalia Wallenbergs minnesfond; Stiftelsen för Strategisk Forskning; National Institute on Aging; National Institute for Health and Care Research; Alexion Pharmaceuticals; Torsten Söderbergs Stiftelse; Apellis Pharmaceuticals; Cytokinetics; Vetenskapsrådet; Parkinsonfonden; Kommunfullmäktige, Stockholms Stad; Agence Nationale de la Recherche; Australian Government; EU Joint Programme – Neurodegenerative Disease Research; Wellcome Trust; Avid Radiopharmaceuticals; Parkinson Research Foundation; NIHR Maudsley Biomedical Research Centre; South London and Maudsley NHS Foundation Trust; Sanofi; Eli Lilly and Company; Motor Neurone Disease Association; Biogen","keywords":"Neurodegeneration; Amyotrophic lateral sclerosis; Medicine; Dementia; Parkinsonism; Biomarker; Frontotemporal dementia; Depression (economics); Internal medicine; Pathology; Oncology; Psychiatry; Disease; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.007131182,0.001317339,0.0006462812,0.0007930354,0.001054008,0.001103738,0.001007804,0.00143722,0.0008731072],"category_scores_gemma":[0.01536543,0.0006807834,0.0007888859,0.0006841049,0.001229157,0.000617019,0.001257324,0.0009142812,0.0006684653],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009751362,"about_ca_system_score_gemma":0.0006656002,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005114326,"about_ca_topic_score_gemma":0.004855634,"domain_scores_codex":[0.9949476,0.002636082,0.0002808971,0.001240216,0.0005763915,0.0003187824],"domain_scores_gemma":[0.9920048,0.002491357,0.001351476,0.00176466,0.001539829,0.0008478638],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.008083407,0.0009323578,0.9776065,0.0000560036,0.0006359586,0.0003133129,0.001627576,0.0001952562,0.005076981,0.0001144406,0.0005172346,0.004840952],"study_design_scores_gemma":[0.0008754224,0.002802539,0.9934881,0.0000147816,0.0001751186,0.0004784617,0.0002542759,0.0005168508,0.0006755707,0.00005209693,0.0006499485,0.00001684007],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998825,0.0001067636,0.0003904218,0.00002530367,0.0000167965,0.0001246493,0.0002395254,0.000009227893,0.0002622409],"genre_scores_gemma":[0.9981537,0.00003374899,0.0004687217,0.00006978483,0.00001509878,0.0001467617,0.0008895754,0.00001078488,0.0002117965],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007131182,"threshold_uncertainty_score":0.03771377,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03151824915561602,"score_gpt":0.340661758102643,"score_spread":0.309143508947027,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}