{"id":"W3167096619","doi":"10.1093/ndt/gfab117.004","title":"FC 040INTERIM RESULTS OF PHASE 1 AND 2 TRIALS TO INVESTIGATE THE SAFETY, TOLERABILITY, PHARMACOKINETICS, PHARMACODYNAMICS, AND CLINICAL ACTIVITY OF BION-1301 IN PATIENTS WITH IGA NEPHROPATHY","year":2021,"lang":"en","type":"article","venue":"Nephrology Dialysis Transplantation","topic":"Renal Diseases and Glomerulopathies","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Chinook Regional Hospital","funders":"","keywords":"Medicine; Tolerability; Nephropathy; Pharmacodynamics; Kidney disease; Pharmacokinetics; Glomerulonephritis; Renal function; Internal medicine; Dialysis; Gastroenterology; Immunology; Proteinuria; Adverse effect; Kidney; Endocrinology; Diabetes mellitus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003013849,0.0008140288,0.001204287,0.0002517058,0.0002578446,0.0006966332,0.0005573181,0.001009519,0.002382211],"category_scores_gemma":[0.001263063,0.0002384551,0.001065215,0.000223226,0.0006017278,0.0006828318,0.0002198848,0.001967201,0.0004479602],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001059179,"about_ca_system_score_gemma":0.0008366207,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004619551,"about_ca_topic_score_gemma":0.0008704375,"domain_scores_codex":[0.9992709,0.0003886176,0.00004040577,0.0001025365,0.0000824071,0.0001151818],"domain_scores_gemma":[0.999209,0.0001865508,0.0001772499,0.00006417626,0.00007429611,0.0002887463],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6746881,0.03524508,0.009441834,0.00137627,0.002339349,0.0002280795,0.0002351279,0.002617614,0.04412216,0.000557641,0.00576763,0.2233811],"study_design_scores_gemma":[0.4039449,0.5596162,0.01744092,0.0001139659,0.001026069,0.000336218,0.00004995413,0.001859115,0.008010656,0.0004824199,0.007080494,0.00003908367],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9805635,0.0110228,0.0009223073,0.0007480563,0.0001824335,0.001717646,0.001089274,0.0001028384,0.003651108],"genre_scores_gemma":[0.98965,0.002370272,0.001500069,0.001164757,0.0001628417,0.001436574,0.001778119,0.00001773928,0.001919697],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003013849,"threshold_uncertainty_score":0.01593894,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02584317685345897,"score_gpt":0.3454346088922529,"score_spread":0.3195914320387939,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}