{"id":"W3167101548","doi":"10.1016/j.jlr.2021.100091","title":"Atherosclerosis-associated hepatic secretion of VLDL but not PCSK9 is dependent on cargo receptor protein Surf4","year":2021,"lang":"en","type":"article","venue":"Journal of Lipid Research","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; Shandong First Medical University; Natural Sciences and Engineering Research Council of Canada; Wuhan University; Children's Health Research Institute; Women and Children's Health Research Institute; National Natural Science Foundation of China","keywords":"PCSK9; LDL receptor; Secretion; Very low-density lipoprotein; Endocrinology; Internal medicine; Receptor; Chemistry; Cholesterol; Lipoprotein; Biology; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002436632,0.0008764342,0.0005659644,0.0007931224,0.0001902018,0.0005251367,0.0003506695,0.0005842305,0.00459365],"category_scores_gemma":[0.0002210447,0.0004034177,0.0005599529,0.0002638761,0.0007973352,0.0003723406,0.0004265053,0.001052737,0.001394582],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004318264,"about_ca_system_score_gemma":0.0002711463,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004577102,"about_ca_topic_score_gemma":0.000576387,"domain_scores_codex":[0.9997031,0.00005223311,0.00004973567,0.00006495533,0.00006489966,0.00006508771],"domain_scores_gemma":[0.999474,0.00005019946,0.0001973446,0.00005520829,0.00003553295,0.0001878024],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003064328,0.000009980227,0.0001477218,0.00002416928,0.000006463136,0.00007077348,0.000007662556,0.00003578607,0.9989004,0.00008517971,0.00002835291,0.0003771246],"study_design_scores_gemma":[0.00004533757,0.0002668021,0.004228131,0.000007840972,0.00003320623,0.0004342667,0.00005706711,0.0006831384,0.9922593,0.000095796,0.001878388,0.00001071645],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990775,0.0005798292,0.005032877,0.0002774116,0.0000629073,0.00002255111,0.00141215,0.0004163528,0.00142085],"genre_scores_gemma":[0.982511,0.0007040077,0.00377624,0.00009394685,0.00002854991,0.00006814291,0.002358087,0.0002978365,0.01016223],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00459365,"threshold_uncertainty_score":0.01536727,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04115542180647958,"score_gpt":0.3243611894304429,"score_spread":0.2832057676239633,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}