{"id":"W3167197164","doi":"10.1038/s41467-021-23673-0","title":"Reinforcing one-carbon metabolism via folic acid/Folr1 promotes β-cell differentiation","year":2021,"lang":"en","type":"article","venue":"Nature Communications","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Novo Nordisk Fonden; NordForsk; Vetenskapsrådet; Novo Nordisk; Karolinska Institutet","keywords":"Zebrafish; Folinic acid; Cellular differentiation; Cell; Cell biology; Biology; Folate receptor; Metabolism; Chemistry; Biochemistry; Genetics; Cancer cell; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00023652,0.0004362246,0.0003790149,0.0003554967,0.0002206623,0.000342958,0.0002987766,0.0004604737,0.001939276],"category_scores_gemma":[0.00016988,0.0001937829,0.0003806754,0.0001403308,0.0002986345,0.000297411,0.0003533131,0.0006702742,0.0003724789],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000477832,"about_ca_system_score_gemma":0.0003494971,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002008539,"about_ca_topic_score_gemma":0.003976799,"domain_scores_codex":[0.999842,0.00002002409,0.00001234086,0.00004844695,0.00004570865,0.00003137737],"domain_scores_gemma":[0.9998504,0.0000252633,0.00005114694,0.00001408041,0.00001850715,0.00004068343],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005570454,0.000006407583,0.0001144576,0.00003433029,0.000004692598,0.00004197819,0.000007174339,0.0000289524,0.9988576,0.00005095844,0.00002105103,0.0007767596],"study_design_scores_gemma":[0.0000229795,0.0002180483,0.003946133,0.00001677398,0.00004222406,0.0001787396,0.00002876716,0.0005169341,0.9916579,0.00005708841,0.003306743,0.000007661669],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9841619,0.003664838,0.006984917,0.0004247831,0.00005957129,0.00006096421,0.0008143051,0.0004290904,0.003399738],"genre_scores_gemma":[0.9866806,0.002150654,0.006593571,0.0001851542,0.00001191068,0.00003899809,0.0005599675,0.00007508259,0.003704128],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002008539,"threshold_uncertainty_score":0.006487489,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02097183073038679,"score_gpt":0.2739977847396958,"score_spread":0.2530259540093091,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}