{"id":"W3167256638","doi":"10.1093/brain/awab217","title":"TDP-43 stabilizes <i>G3BP1</i> mRNA: relevance to amyotrophic lateral sclerosis/frontotemporal dementia","year":2021,"lang":"en","type":"article","venue":"Brain","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":62,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Health Science Centre; Health Sciences Centre; Occupational Cancer Research Centre; University of Toronto; Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"National Institute on Aging; National Institutes of Health; National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; ALS Society of Canada; Muscular Dystrophy Association","keywords":"Amyotrophic lateral sclerosis; Frontotemporal dementia; Neuroscience; Medicine; Psychology; Dementia; Disease; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0005001199,0.0003514658,0.00059778,0.0001339722,0.0001983049,0.000137527,0.0003006348,0.0001920428,0.002063865],"category_scores_gemma":[0.0008279181,0.0003159146,0.0002326926,0.0007059633,0.0001451041,0.0002498295,0.0003935889,0.0005047715,0.0007899235],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002893119,"about_ca_system_score_gemma":0.0003832258,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002626732,"about_ca_topic_score_gemma":0.000208052,"domain_scores_codex":[0.996274,0.0002689012,0.0005900624,0.0008832336,0.0009875086,0.000996312],"domain_scores_gemma":[0.9977529,0.0001670019,0.00008933717,0.0009401774,0.0003601219,0.000690462],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0008951984,0.0006327436,0.06779375,0.0002737319,0.000409049,0.0008363425,0.000808374,0.0001184547,0.8129528,0.0006527209,0.09872933,0.01589752],"study_design_scores_gemma":[0.004134017,0.0007735335,0.8545529,0.00063468,0.000104375,0.0001041423,0.00009421036,0.0002963038,0.0115601,0.0005567791,0.1265533,0.0006356522],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9485947,0.001480518,0.0002612402,0.04572047,0.000341383,0.0007120028,0.00003877367,0.0001986392,0.002652265],"genre_scores_gemma":[0.9745241,0.0002249475,0.006560514,0.007909137,0.0005054359,0.00010169,0.00007699678,0.00009463243,0.01000256],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8013927,"threshold_uncertainty_score":0.9999881,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04136886192414497,"score_gpt":0.2974051846922018,"score_spread":0.2560363227680568,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}