{"id":"W3167271619","doi":"10.1096/fasebj.2021.35.s1.02463","title":"Receptor Endocytosis as a Mechanism of Biased Agonism at CXCR3","year":2021,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Trinity College","funders":"","keywords":"G protein-coupled receptor; Internalization; Cell biology; Endosome; Chemokine receptor; Functional selectivity; Biology; Endocytic cycle; Chemistry; Arrestin; Receptor; Signal transduction; Endocytosis; Chemokine; Biochemistry; Intracellular","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003968081,0.0003564304,0.0005339918,0.0002269116,0.0003279915,0.0005639032,0.0004696158,0.0006946818,0.001211245],"category_scores_gemma":[0.0001952224,0.0002382821,0.000813943,0.0001705965,0.0004045798,0.000795019,0.000460078,0.001095566,0.0004047056],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008050381,"about_ca_system_score_gemma":0.0004385066,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009511377,"about_ca_topic_score_gemma":0.0008192983,"domain_scores_codex":[0.9994788,0.00007595152,0.00003201442,0.00006489283,0.0001373845,0.0002110356],"domain_scores_gemma":[0.9998821,0.00002679649,0.00002977963,0.00001746039,0.00002462638,0.00001919629],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000158743,0.00002214493,0.0004193161,0.00007448284,0.000009880071,0.0001854126,0.00003344192,0.0001879259,0.9969161,0.001092171,0.00007170073,0.0008287628],"study_design_scores_gemma":[0.00004278134,0.0002612597,0.009646286,0.00002479018,0.00003387744,0.001368816,0.00008935567,0.004853539,0.9810734,0.000428032,0.002155855,0.00002187709],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9830695,0.003913734,0.009211501,0.0004562254,0.00005645895,0.00007890541,0.000353473,0.00009862865,0.002761527],"genre_scores_gemma":[0.9932915,0.001380257,0.003296433,0.0002695219,0.00001073385,0.00004836324,0.0002145605,0.0000179895,0.001470638],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001211245,"threshold_uncertainty_score":0.005840957,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01451894127891671,"score_gpt":0.2382146053243841,"score_spread":0.2236956640454674,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}