{"id":"W3167303800","doi":"10.1200/jco.2021.39.15_suppl.10020","title":"Low-dose metronomic topotecan and pazopanib in children with recurrent or refractory solid tumors: A C17 Canadian phase I trial (TOPAZ).","year":2021,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Neuroblastoma Research and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital; University of Calgary; Children's Hospital of Eastern Ontario; London Health Sciences Centre; Centre Hospitalier Universitaire Sainte-Justine; C17 Council; University of Toronto; BC Children's Hospital; SickKids Foundation; Hospital for Sick Children","funders":"Novartis","keywords":"Medicine; Pazopanib; Neutropenia; Internal medicine; Rhabdomyosarcoma; Topotecan; Adverse effect; Pharmacokinetics; Cmax; Febrile neutropenia; Gastroenterology; Oncology; Sarcoma; Surgery; Toxicity; Chemotherapy; Cancer; Sunitinib; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008166155,0.0008517762,0.001116254,0.0001925952,0.0003805515,0.000574581,0.0008205379,0.0005448441,0.00190716],"category_scores_gemma":[0.0003873241,0.000230352,0.0006214242,0.0006372753,0.0005805754,0.0002284696,0.0002614502,0.001740995,0.000252974],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.005479228,"about_ca_system_score_gemma":0.01043728,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.158615,"about_ca_topic_score_gemma":0.3949686,"domain_scores_codex":[0.9997508,0.00007412198,0.00001066319,0.00003542658,0.00005835594,0.00007062442],"domain_scores_gemma":[0.9995571,0.00003717789,0.00006688058,0.00001040286,0.0000419279,0.0002865684],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.3942336,0.02070907,0.08612526,0.003547491,0.004093247,0.002523171,0.001080671,0.008133227,0.04845228,0.001909817,0.05694565,0.3722464],"study_design_scores_gemma":[0.5278143,0.176162,0.2220062,0.0003552332,0.003317483,0.002960355,0.0003531747,0.004055864,0.008899585,0.0003944501,0.05358414,0.00009721395],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9794509,0.01054707,0.0003787937,0.001499612,0.00006561413,0.001215909,0.002965159,0.00008421752,0.003792717],"genre_scores_gemma":[0.9794071,0.007647244,0.002904559,0.001161796,0.00009627827,0.0008827592,0.00538472,0.00002999333,0.002485487],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.158615,"threshold_uncertainty_score":0.3153834,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1005701201722542,"score_gpt":0.4840360349547482,"score_spread":0.383465914782494,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}