{"id":"W3167394795","doi":"10.1096/fasebj.2021.35.s1.02824","title":"Dynamic Response of Arterial Cerebral Ca <sub>V</sub> 1.2 Channels to Intravascular Pressure","year":2021,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Caveolin-1 and cellular processes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Mechanosensitive channels; Caveolae; Electrophysiology; Gating; Biophysics; Vascular smooth muscle; Cav1.2; Myogenic contraction; Cell biology; BAPTA; Depolarization; Patch clamp; Neuroscience; Chemistry; Biology; Intracellular; Ion channel; Internal medicine; Signal transduction; Voltage-dependent calcium channel; Endocrinology; Medicine; Calcium; Biochemistry; Smooth muscle","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001037421,0.0001405747,0.0001975829,0.00009424847,0.000118685,0.0003378581,0.0002282961,0.0003041357,0.001138519],"category_scores_gemma":[0.0003013283,0.0001070079,0.0001073127,0.00008857575,0.0001988719,0.0003081365,0.0001368199,0.0004300194,0.000224551],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002766879,"about_ca_system_score_gemma":0.0001165076,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006135426,"about_ca_topic_score_gemma":0.0006049855,"domain_scores_codex":[0.9998894,0.00001127567,0.000004151605,0.00001885168,0.00002573299,0.0000505606],"domain_scores_gemma":[0.9998968,0.00002801391,0.00002673522,0.000009207891,0.00001317473,0.00002602788],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003364788,0.00001908203,0.0005193063,0.00002936574,0.000007091035,0.0001495473,0.00002768608,0.0001098045,0.995895,0.0001868197,0.000181278,0.002538572],"study_design_scores_gemma":[0.00008784275,0.0005670237,0.1267511,0.00001391148,0.00006283438,0.0009654214,0.0001795312,0.01030441,0.8567411,0.0007697546,0.003528755,0.00002825948],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958729,0.001050948,0.001388629,0.0002594843,0.00002439504,0.00001131813,0.0001363497,0.00006212229,0.001193927],"genre_scores_gemma":[0.998414,0.0004507147,0.0002873018,0.00009122186,0.00003121323,0.00002497208,0.00009049471,0.000006839722,0.0006031893],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001138519,"threshold_uncertainty_score":0.003808677,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005145931245459288,"score_gpt":0.2145332351762163,"score_spread":0.209387303930757,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}