{"id":"W3167456795","doi":"10.1002/art.41888","title":"Optimizing the Start Time of Biologics in Polyarticular Juvenile Idiopathic Arthritis: A Comparative Effectiveness Study of Childhood Arthritis and Rheumatology Research Alliance Consensus Treatment Plans","year":2021,"lang":"en","type":"article","venue":"Arthritis & Rheumatology","topic":"Autoimmune and Inflammatory Disorders Research","field":"Medicine","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"H2020 European Research Council; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Swedish Orphan Biovitrum; National Institutes of Health; Sanofi; Childhood Arthritis and Rheumatology Research Alliance; Rheumatology Research Foundation; Pfizer; Patient-Centered Outcomes Research Institute; Eli Lilly and Company; Bristol-Myers Squibb; Genentech; Arthritis Foundation","keywords":"Medicine; Internal medicine; Rheumatology; Observational study; Arthritis; Physical therapy; Antirheumatic drugs; Disease; Biosimilar; Antirheumatic Agents","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01385822,0.0007359676,0.001587533,0.001092628,0.0003498951,0.001021727,0.001000241,0.001356758,0.003310405],"category_scores_gemma":[0.02541221,0.0004050786,0.003195939,0.0009213146,0.0007179658,0.001531155,0.000790239,0.001617569,0.0001752071],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002013036,"about_ca_system_score_gemma":0.001539871,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001538008,"about_ca_topic_score_gemma":0.001575423,"domain_scores_codex":[0.9828619,0.01291297,0.001123809,0.001014852,0.001637019,0.0004493743],"domain_scores_gemma":[0.9773504,0.01422886,0.005807448,0.0008353363,0.000471398,0.001306645],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.6792693,0.03261751,0.07612728,0.003950122,0.02083571,0.00008623079,0.0005683986,0.008552148,0.0007291276,0.001927188,0.001076969,0.1742601],"study_design_scores_gemma":[0.3724357,0.4531198,0.1361266,0.001447243,0.01737466,0.0003080423,0.0007346541,0.0133663,0.001040977,0.001251832,0.002639711,0.0001545909],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9847291,0.01109874,0.0007908163,0.000241848,0.0001016524,0.0008576729,0.0004321166,0.00001239726,0.00173564],"genre_scores_gemma":[0.9950694,0.002460312,0.001148653,0.0001204786,0.00008484744,0.0006473454,0.0003238674,0.000004459484,0.0001406598],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01385822,"threshold_uncertainty_score":0.07329011,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03887260248920518,"score_gpt":0.3245607160418282,"score_spread":0.285688113552623,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}