{"id":"W3167483544","doi":"10.1186/s12915-021-01046-9","title":"The Wnt-specific astacin proteinase HAS-7 restricts head organizer formation in Hydra","year":2021,"lang":"en","type":"article","venue":"BMC Biology","topic":"Marine Invertebrate Physiology and Ecology","field":"Earth and Planetary Sciences","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Canadian Institutes of Health Research; Universität Heidelberg; Deutsche Forschungsgemeinschaft","keywords":"Lernaean Hydra; Biology; Wnt signaling pathway; Cell biology; Xenopus; Zebrafish; Gene knockdown; Signal transduction; Genetics; Cell culture; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006623064,0.0002256036,0.0002183091,0.0001904689,0.0001570526,0.0003082425,0.0001981281,0.0002189709,0.001360407],"category_scores_gemma":[0.00007969983,0.0002405924,0.0002649735,0.00009101201,0.0003507332,0.000149753,0.0004642763,0.0004328804,0.0005871959],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003786361,"about_ca_system_score_gemma":0.00030566,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001183067,"about_ca_topic_score_gemma":0.002212969,"domain_scores_codex":[0.9999255,0.000005722939,0.00000601077,0.00001818889,0.0000279496,0.0000167162],"domain_scores_gemma":[0.9998772,0.00001766853,0.00003536459,0.00001150228,0.00001341665,0.0000446959],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002564726,0.000001901684,0.0002230112,0.00001623906,0.000002264568,0.00002171465,0.000005521113,0.00002714365,0.9994362,0.00003356284,0.00001401419,0.0001928211],"study_design_scores_gemma":[0.00001155131,0.00009094441,0.02532871,0.000007855776,0.00001885107,0.0002560635,0.00006868668,0.001752555,0.9694473,0.00006484323,0.002946047,0.000006590316],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956282,0.0006284769,0.00201006,0.00005371866,0.00001184412,0.00001420577,0.0003892354,0.00005535868,0.001208852],"genre_scores_gemma":[0.9941046,0.0003389044,0.001406884,0.00003685064,0.000004846063,0.00002114039,0.0005970015,0.00004684397,0.003443097],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001360407,"threshold_uncertainty_score":0.004551053,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04135682462097359,"score_gpt":0.2277976907550771,"score_spread":0.1864408661341035,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}