{"id":"W3167499254","doi":"10.3389/fimmu.2021.669943","title":"Thymic Epithelial Cell Alterations and Defective Thymopoiesis Lead to Central and Peripheral Tolerance Perturbation in MHCII Deficiency","year":2021,"lang":"en","type":"article","venue":"Frontiers in Immunology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"National Institute of Allergy and Infectious Diseases; NHLBI Division of Intramural Research; National Institutes of Health; Division of Intramural Research, National Institute of Allergy and Infectious Diseases","keywords":"Primary immunodeficiency; Biology; Immunology; Immune dysregulation; Immune system; Peripheral tolerance; Immunodeficiency; Autoimmunity; Central tolerance; Major histocompatibility complex; T cell; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001104836,0.0003516514,0.000248706,0.0004021366,0.0001238197,0.00032327,0.0001359848,0.0003029986,0.0009513602],"category_scores_gemma":[0.0001357317,0.0001372805,0.0002060597,0.0001776274,0.0002605275,0.0001352119,0.0003037479,0.0004557632,0.0002720615],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001094757,"about_ca_system_score_gemma":0.00007812832,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001207742,"about_ca_topic_score_gemma":0.0001612688,"domain_scores_codex":[0.9998661,0.00002053129,0.0000146228,0.00003831787,0.00003147298,0.00002883428],"domain_scores_gemma":[0.9998571,0.00001500576,0.00005440655,0.00001185241,0.000009511878,0.00005212788],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001580524,0.00001373308,0.002884666,0.00003822297,0.000008485075,0.0008018777,0.00002723476,0.00003751002,0.9947766,0.00004724428,0.00002604428,0.001180254],"study_design_scores_gemma":[0.00004102096,0.0006441031,0.2396619,0.00003864051,0.0001203358,0.0274187,0.0003648046,0.001423957,0.7261796,0.000394343,0.003694414,0.00001816874],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969949,0.001035451,0.00126459,0.00002126718,0.000008152143,0.000008173223,0.0001732534,0.00004994759,0.0004442887],"genre_scores_gemma":[0.9979242,0.0006319808,0.0006413934,0.00002917368,0.000007388949,0.000006752378,0.0002218364,0.00001243339,0.0005248542],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009513602,"threshold_uncertainty_score":0.00318259,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00517071097090964,"score_gpt":0.2021592098920745,"score_spread":0.1969884989211649,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}