{"id":"W3167506735","doi":"10.1158/1557-3265.ovcasymp18-nt-118","title":"Abstract NT-118: SEQUENTIAL THERAPEUTIC TARGETING OF OVARIAN CANCER HARBORING DYSFUNCTIONAL BRCA1","year":2019,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital; McGill University","funders":"","keywords":"Ovarian cancer; Olaparib; Chemotherapy; Medicine; Cancer research; Cisplatin; Paclitaxel; Debulking; Cancer; Oncology; PARP inhibitor; Carboplatin; Doxorubicin; Internal medicine; Biology; Poly ADP ribose polymerase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007067983,0.0002268616,0.000279698,0.0001700768,0.0001061789,0.0001887012,0.000291954,0.0002174281,0.00250129],"category_scores_gemma":[0.00009103831,0.00007674687,0.0002134505,0.000157958,0.0001199633,0.0001814011,0.0001473379,0.000519416,0.000285417],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002130738,"about_ca_system_score_gemma":0.0002271726,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004845975,"about_ca_topic_score_gemma":0.0006285782,"domain_scores_codex":[0.999951,0.000005754116,0.000004874456,0.00001111804,0.00001653511,0.00001063448],"domain_scores_gemma":[0.99997,0.000003429405,0.000006835905,0.000003750736,0.000005894268,0.00001018298],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002513913,0.000710114,0.0006283694,0.0004814389,0.00003684924,0.0002243888,0.0000334534,0.0006028599,0.9513552,0.0003540868,0.002024311,0.04103497],"study_design_scores_gemma":[0.0007373761,0.008970037,0.005767964,0.0000374598,0.0001372088,0.002543147,0.00004626713,0.002693394,0.9565605,0.0002085297,0.0222809,0.00001727218],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9836272,0.006207718,0.003098123,0.0002811083,0.0001828975,0.0001606892,0.001092161,0.0001637835,0.005186327],"genre_scores_gemma":[0.9905944,0.002310241,0.00229131,0.0001180993,0.00002359964,0.0001063854,0.001382407,0.00001854747,0.003154914],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00250129,"threshold_uncertainty_score":0.008367598,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2990487219853393,"score_gpt":0.5437371260757348,"score_spread":0.2446884040903954,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}