{"id":"W3167507754","doi":"10.2147/copd.s294333","title":"Mepolizumab for Eosinophil-Associated COPD: Analysis of METREX and METREO","year":2021,"lang":"en","type":"review","venue":"International Journal of COPD","topic":"Chronic Obstructive Pulmonary Disease (COPD) Research","field":"Medicine","cited_by":82,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"European Respiratory Society; GlaxoSmithKline; American Thoracic Society","keywords":"Mepolizumab; Medicine; Exacerbation; Internal medicine; Placebo; COPD; Clinical endpoint; Eosinophil; Randomized controlled trial; Hazard ratio; Confidence interval; Gastroenterology; Pathology; Asthma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000740953,0.0003594502,0.003267159,0.002557518,0.00004063716,0.00006739421,0.000534474,0.0002456738,0.0007484053],"category_scores_gemma":[0.00183327,0.0002949421,0.0023259,0.001286798,0.0001662921,0.0001417857,0.0001810617,0.000544705,0.000003728359],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0013429,"about_ca_system_score_gemma":0.001925923,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005481071,"about_ca_topic_score_gemma":0.00002044011,"domain_scores_codex":[0.9958169,0.0002485009,0.001613086,0.0003551765,0.001679503,0.0002868157],"domain_scores_gemma":[0.9929888,0.001102991,0.001821738,0.000287455,0.00348602,0.000313047],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003704393,0.0009001497,0.001045513,0.005946465,0.0892432,0.001216571,0.00007181903,0.00001266726,0.0000147059,0.0009287524,0.005186566,0.8950632],"study_design_scores_gemma":[0.003806033,0.0003280287,0.005049846,0.01573814,0.04871027,0.001022088,0.0001155083,0.0004152686,0.00002877455,0.0002037209,0.9241766,0.000405748],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001003968,0.9956592,0.0001775798,0.0003671895,0.0005688351,0.0004602263,0.001104533,0.00000766449,0.0006508466],"genre_scores_gemma":[0.005353264,0.99176,0.0005326488,0.00006358558,0.0005073348,0.00002102749,0.0007122071,0.0000596783,0.0009902474],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.91899,"threshold_uncertainty_score":0.9999503,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05257673057627094,"score_gpt":0.41373496738615,"score_spread":0.361158236809879,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}