{"id":"W3167544053","doi":"10.1016/j.neulet.2021.136011","title":"Genetically and pharmacologically limiting RyR2 open time prevents neuronal hyperactivity of hippocampal CA1 neurons in brain slices of 5xFAD mice","year":2021,"lang":"en","type":"article","venue":"Neuroscience Letters","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":7,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hotchkiss Brain Institute; Libin Cardiovascular Institute of Alberta; University of Calgary","funders":"Canadian Institutes of Health Research; Heart and Stroke Foundation of Canada","keywords":"Hippocampal formation; Neuroscience; Calcium imaging; Premovement neuronal activity; In vivo; Hippocampus; Chemistry; Biological neural network; Biology; Calcium","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0008048308,0.0003145746,0.0005403165,0.0002944702,0.0002763474,0.0001711602,0.001861205,0.00007645291,0.00009337135],"category_scores_gemma":[0.003383715,0.0003094847,0.00009885812,0.001735475,0.001760417,0.0009163923,0.001697363,0.0007538646,0.000009883594],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002595556,"about_ca_system_score_gemma":0.0003012283,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001783195,"about_ca_topic_score_gemma":0.000003223452,"domain_scores_codex":[0.9940925,0.001787503,0.0006792194,0.001602179,0.0009325189,0.0009061357],"domain_scores_gemma":[0.9965473,0.002359893,0.000337095,0.0004025323,0.00007026011,0.0002828731],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001406101,0.0005300747,0.01058709,0.00003682709,0.000001100004,0.0006794188,0.00006681884,0.0002518092,0.9862155,0.00004088433,0.0002264961,0.001223378],"study_design_scores_gemma":[0.0009807382,0.0004266028,0.07705492,0.00002617244,0.00001198694,0.0002342333,0.000009143525,0.002988314,0.9175979,0.00003189161,0.0004086123,0.0002294882],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9870076,0.00001344189,0.00001974031,0.01152727,0.0004108145,0.0006210355,0.00004034862,0.00003055608,0.0003292093],"genre_scores_gemma":[0.9626024,0.0001258676,0.0001426241,0.03685389,0.00003496964,0.00003207903,4.760566e-7,0.00002729907,0.0001803615],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06861759,"threshold_uncertainty_score":0.9999357,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06834722017336109,"score_gpt":0.3619505949648754,"score_spread":0.2936033747915143,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}