{"id":"W3167579387","doi":"10.1038/s41380-021-01175-1","title":"Reversing frontal disinhibition rescues behavioural deficits in models of CACNA1A-associated neurodevelopment disorders","year":2021,"lang":"en","type":"article","venue":"Molecular Psychiatry","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":32,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"Canadian Institutes of Health Research","keywords":"Neuroscience; Disinhibition; Impulsivity; Prefrontal cortex; Haploinsufficiency; Parvalbumin; Psychology; Epilepsy; Neurocognitive; Cognition; Biology; Psychiatry; Phenotype; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002489264,0.001189405,0.0007205863,0.001086151,0.0005781871,0.0005761566,0.001166741,0.001033432,0.002978287],"category_scores_gemma":[0.0003875304,0.0002991283,0.0005189652,0.0002913409,0.001157598,0.0004441964,0.0004092564,0.002498954,0.0007502954],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001069224,"about_ca_system_score_gemma":0.001243768,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007070216,"about_ca_topic_score_gemma":0.01227143,"domain_scores_codex":[0.9997178,0.0000285811,0.00002491662,0.00007118509,0.00006902292,0.00008851654],"domain_scores_gemma":[0.9996025,0.00003583325,0.0001128537,0.0000522697,0.00004033912,0.0001561497],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001394029,0.0005390175,0.0003179824,0.0001655337,0.00007856361,0.0006170443,0.00007495405,0.0005120658,0.9855345,0.0007165711,0.0008025193,0.009247174],"study_design_scores_gemma":[0.0004759828,0.002878101,0.00914182,0.0001325464,0.0002055295,0.001500123,0.0003538614,0.003476146,0.967207,0.00111249,0.01344741,0.00006896774],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9855928,0.003318528,0.003491713,0.001080011,0.0004641621,0.0001350818,0.001441879,0.0009008585,0.003574866],"genre_scores_gemma":[0.9878301,0.002771196,0.002050888,0.0002285856,0.00004480492,0.0001813599,0.0009881216,0.0001324493,0.005772538],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007070216,"threshold_uncertainty_score":0.01405811,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03564722055241727,"score_gpt":0.2969705746478996,"score_spread":0.2613233540954824,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}