{"id":"W3167581577","doi":"10.1016/j.freeradbiomed.2021.06.005","title":"Global Reach 2018: Nitric oxide-mediated cutaneous vasodilation is reduced in chronic, but not acute, hypoxia independently of enzymatic superoxide formation","year":2021,"lang":"en","type":"article","venue":"Free Radical Biology and Medicine","topic":"Thermoregulation and physiological responses","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta; Okanagan University College; University of British Columbia, Okanagan Campus; University of British Columbia; Western University","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Higher Education Funding Council for Wales; Royal Society","keywords":"Xanthine oxidase; Superoxide; Vasodilation; Hypoxia (environmental); Chemistry; Nitric oxide; NADPH oxidase; Allopurinol; Endocrinology; Apocynin; Internal medicine; Anesthesia; Pharmacology; Medicine; Reactive oxygen species; Oxygen; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003830646,0.0003339257,0.0004732731,0.0002797604,0.0003766622,0.001006163,0.0004697962,0.0007499884,0.01531991],"category_scores_gemma":[0.0004484622,0.0001964777,0.0003753164,0.0002855645,0.0004480114,0.0008603365,0.0009249015,0.0009111029,0.001764612],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003377121,"about_ca_system_score_gemma":0.0006685166,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006354116,"about_ca_topic_score_gemma":0.0008204061,"domain_scores_codex":[0.9998135,0.00001461209,0.000009081156,0.00005336097,0.00006263376,0.00004677405],"domain_scores_gemma":[0.9996356,0.00003298781,0.00008619836,0.0000380999,0.00007990861,0.0001271921],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004647963,0.0001910825,0.005946871,0.001129765,0.0001541763,0.0002801997,0.0003402972,0.000292974,0.8734723,0.004474285,0.01774064,0.09132939],"study_design_scores_gemma":[0.0005306554,0.003691398,0.3197451,0.0003997286,0.0006014656,0.002002422,0.0006648761,0.003103932,0.4741966,0.007955251,0.1869829,0.0001257136],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9108309,0.01134516,0.0157942,0.004907915,0.002628872,0.0001282242,0.005255672,0.002371899,0.04673731],"genre_scores_gemma":[0.9569706,0.00298307,0.002691846,0.0009303158,0.0004345159,0.0001296016,0.005099835,0.0004799248,0.0302803],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01531991,"threshold_uncertainty_score":0.05125022,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02368923463106222,"score_gpt":0.3042135585197064,"score_spread":0.2805243238886442,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}