{"id":"W3167621867","doi":"10.3390/antiox10060931","title":"Oxidative Stress as A Mechanism for Functional Alterations in Cardiac Hypertrophy and Heart Failure","year":2021,"lang":"en","type":"review","venue":"Antioxidants","topic":"Cardiac Fibrosis and Remodeling","field":"Medicine","cited_by":171,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; St. Boniface Hospital","funders":"","keywords":"Internal medicine; Heart failure; Angiotensin II; Oxidative stress; Endocrinology; Muscle hypertrophy; Medicine; NADPH oxidase; Pressure overload; Hormone; Cardiac function curve; Blood pressure; Cardiac hypertrophy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008893213,0.0006796683,0.0005309137,0.001215038,0.0005213057,0.0005676468,0.0008141086,0.00100104,0.001538848],"category_scores_gemma":[0.0004079671,0.000274635,0.0006068503,0.0003873873,0.0008423506,0.0007266488,0.0009148233,0.001074605,0.0002531825],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005044944,"about_ca_system_score_gemma":0.0004325428,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005295156,"about_ca_topic_score_gemma":0.0004693305,"domain_scores_codex":[0.9995857,0.0001106914,0.00004044858,0.00007494564,0.0001060627,0.00008220892],"domain_scores_gemma":[0.9996617,0.00003641782,0.0001383935,0.00002386095,0.0000759626,0.00006374057],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.004897066,0.003141307,0.110519,0.009429414,0.001445443,0.01986423,0.002976205,0.001668285,0.5914465,0.03567638,0.01135733,0.2075788],"study_design_scores_gemma":[0.0008107644,0.01198113,0.6112435,0.002671497,0.001736419,0.04185765,0.00264555,0.006606931,0.1490318,0.06218435,0.1089512,0.0002791356],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.4593561,0.4944154,0.01924782,0.006808485,0.001977862,0.0006050235,0.0004930176,0.0003383368,0.01675796],"genre_scores_gemma":[0.9255808,0.06518941,0.002764009,0.001169139,0.0008855927,0.0002083307,0.0002540096,0.00001017806,0.003938517],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001538848,"threshold_uncertainty_score":0.005147934,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04117776689734115,"score_gpt":0.3225532363224836,"score_spread":0.2813754694251425,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}