{"id":"W3167638583","doi":"10.3390/ijms22126425","title":"Radiodynamic Therapy Using TAT Peptide-Targeted Verteporfin-Encapsulated PLGA Nanoparticles","year":2021,"lang":"en","type":"article","venue":"International Journal of Molecular Sciences","topic":"Nanoplatforms for cancer theranostics","field":"Engineering","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"Australian Research Council; University of New South Wales","keywords":"Photosensitizer; Verteporfin; Photodynamic therapy; PLGA; Clonogenic assay; Cytotoxicity; Cancer research; Nanocarriers; Chemistry; Cell-penetrating peptide; Drug delivery; Biophysics; In vitro; Peptide; Materials science; Nanotechnology; Medicine; Biochemistry; Photochemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008533258,0.0002235421,0.000167776,0.0001434403,0.0001013655,0.0002393592,0.0001704871,0.000290927,0.000292644],"category_scores_gemma":[0.00008567634,0.0001038431,0.000133227,0.0000872136,0.0001741723,0.0002172466,0.0001288073,0.0001714526,0.0001179932],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003979103,"about_ca_system_score_gemma":0.000140035,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00105484,"about_ca_topic_score_gemma":0.001037575,"domain_scores_codex":[0.9999281,0.000008714122,0.000002984456,0.00002647994,0.00001554201,0.000018188],"domain_scores_gemma":[0.9999603,0.000008490861,0.0000159124,0.00000379141,0.000004502875,0.000007074173],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000353303,0.00001636475,0.00005327084,0.00002019572,0.000002667312,0.00003156711,0.00001347315,0.0005884478,0.9967884,0.00009768749,0.00003507461,0.002317594],"study_design_scores_gemma":[0.000007393619,0.0001850882,0.0003650505,0.00000251232,0.000005526096,0.0001042633,0.000006380096,0.002064168,0.9961248,0.00001657702,0.001114501,0.000003770738],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9818954,0.001176115,0.01528637,0.00009007147,0.00002270064,0.00003736095,0.00006225136,0.0001569719,0.001272644],"genre_scores_gemma":[0.9928842,0.000502929,0.005053018,0.00002982546,0.000005629874,0.0000216502,0.00004849038,0.00001718877,0.001437131],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00105484,"threshold_uncertainty_score":0.002887011,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01605550549551939,"score_gpt":0.2575011726324789,"score_spread":0.2414456671369595,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}