{"id":"W3167707232","doi":"10.1002/brb3.2222","title":"Lamotrigine for acute bipolar depression: An exploratory item‐level analysis","year":2021,"lang":"en","type":"article","venue":"Brain and Behavior","topic":"Bipolar Disorder and Treatment","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; University of Alberta; University of Saskatchewan","funders":"","keywords":"Lamotrigine; Anhedonia; Rating scale; Psychology; Depression (economics); Mood; Bipolar disorder; Psychiatry; Placebo; Clinical psychology; Dysphoria; Atypical depression; Sadness; Randomized controlled trial; Hamilton Rating Scale for Depression; Major depressive disorder; Medicine; Internal medicine; Schizophrenia (object-oriented programming); Anger; Epilepsy; Developmental psychology; Anxiety","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008445297,0.0001386141,0.0003000644,0.0001183545,0.0001083797,0.00002841928,0.00003700169,0.00009030166,0.0001504383],"category_scores_gemma":[0.00002179011,0.0001107905,0.0001622104,0.0003017848,0.00003079912,0.00009059912,0.00003032764,0.00007421593,0.000004811675],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000173226,"about_ca_system_score_gemma":0.00006976225,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001625255,"about_ca_topic_score_gemma":0.0003139092,"domain_scores_codex":[0.9991721,0.00003326274,0.0001518655,0.0003297983,0.0001333845,0.0001796266],"domain_scores_gemma":[0.9993249,0.00004455942,0.00003186339,0.0003022724,0.00009336373,0.0002030182],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0000869892,0.001483452,0.8668735,0.00004648567,0.0009668847,0.0001629822,0.0003645011,1.750589e-7,0.02149619,0.00006614919,0.0004952672,0.1079574],"study_design_scores_gemma":[0.00277253,0.0002577539,0.9502025,0.00001983081,0.0105106,0.00009527752,0.0002392649,0.0000645943,0.01320908,0.00001645204,0.02243796,0.0001741398],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9829552,0.01429552,0.001110839,0.0008512856,0.00007261195,0.0003792705,0.0002138298,0.00006301634,0.0000584325],"genre_scores_gemma":[0.9909354,0.0003655271,0.004013627,0.0005270887,0.0001004698,0.0002372203,0.0008239154,0.00002838641,0.002968338],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1077833,"threshold_uncertainty_score":0.4517906,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0453076205279937,"score_gpt":0.3422626679711102,"score_spread":0.2969550474431165,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}