{"id":"W3167801050","doi":"10.1128/aac.00760-21","title":"Mutations in a Membrane Permease or <i>hpt</i> Lead to 6-Thioguanine Resistance in Staphylococcus aureus","year":2021,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Antimicrobial Resistance in Staphylococcus","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Canadian Institutes of Health Research; Government of Canada","keywords":"Staphylococcus aureus; Permease; Microbiology; Biology; Major facilitator superfamily; Mutant; Gene; Biochemistry; Bacteria; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001220039,0.0003249026,0.0001612183,0.0002068597,0.0001443691,0.0003262914,0.0002055983,0.0004630553,0.002825625],"category_scores_gemma":[0.0002062043,0.0001385284,0.000243676,0.0001127181,0.0002426651,0.0001955773,0.0002459412,0.0005506484,0.0009859364],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002174971,"about_ca_system_score_gemma":0.0001535335,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006753947,"about_ca_topic_score_gemma":0.0006904537,"domain_scores_codex":[0.9998397,0.00003855916,0.00001692757,0.00002959293,0.00005190107,0.00002339782],"domain_scores_gemma":[0.9998984,0.00001924833,0.00003635839,0.00001682601,0.000008808276,0.0000202523],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004962434,0.00002016818,0.000176438,0.00002194647,0.000006238154,0.0001116086,0.00001151665,0.00004590736,0.9969823,0.00017172,0.000084171,0.00231831],"study_design_scores_gemma":[0.00001109345,0.0002879635,0.002843296,0.000008826687,0.00001399164,0.001510987,0.00002371973,0.0006351933,0.9912219,0.00008432992,0.0033524,0.000006383663],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9820117,0.001465305,0.01008563,0.0003272557,0.00009505355,0.00006004714,0.0006988389,0.0004422549,0.004813971],"genre_scores_gemma":[0.9937277,0.0004963154,0.003024571,0.00005668031,0.00001152839,0.00002147677,0.0004629125,0.0000488531,0.002149979],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002825625,"threshold_uncertainty_score":0.009452641,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0196218133379117,"score_gpt":0.2922695440110165,"score_spread":0.2726477306731048,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}