{"id":"W3167875224","doi":"10.1096/fasebj.2021.35.s1.01936","title":"Limited Capacity for Clearance of Adenosine from the preBötzinger Complex Inspiratory Network Contributes to the Profound Depression of Breathing by Hypoxia in the Very Young","year":2021,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Neuroscience of respiration and sleep","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women and Children’s Health Research Institute; University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Hypoxia (environmental); Apnea; Adenosine; Intermittent hypoxia; Ventilation (architecture); Medicine; Apnea of prematurity; Hypoxic ventilatory response; Breathing; Respiratory system; Anesthesia; Internal medicine; Biology; Chemistry; Obstructive sleep apnea; Gestational age","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002406732,0.0002902831,0.0005106878,0.0002884345,0.0002474779,0.0006498441,0.0004037392,0.0005235957,0.001503828],"category_scores_gemma":[0.0007585254,0.0002729823,0.0003520726,0.0001133875,0.0004589216,0.0003550067,0.0005232757,0.0007319594,0.0005129544],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00039838,"about_ca_system_score_gemma":0.0005169824,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001750335,"about_ca_topic_score_gemma":0.001451116,"domain_scores_codex":[0.999821,0.00002780549,0.00002101759,0.00004997281,0.00003936313,0.00004092849],"domain_scores_gemma":[0.9993829,0.00008779207,0.0002468497,0.00004419728,0.00007246719,0.0001658406],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001357004,0.0001666777,0.0676285,0.0007814423,0.0001455417,0.006266461,0.0004363004,0.0003900638,0.8686984,0.004063869,0.001412561,0.0486532],"study_design_scores_gemma":[0.00006651424,0.002302026,0.7318933,0.0003012725,0.0004242493,0.01846505,0.0009099133,0.003103895,0.2183074,0.003750496,0.0204098,0.00006612513],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9586152,0.02924587,0.006319027,0.0008143093,0.0001404175,0.00004729657,0.0004560013,0.0001107285,0.004251042],"genre_scores_gemma":[0.987579,0.007747328,0.001748231,0.000243406,0.00009397132,0.00004799141,0.0002832862,0.00003139152,0.002225432],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001750335,"threshold_uncertainty_score":0.005030811,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06223729705977148,"score_gpt":0.2750124658390209,"score_spread":0.2127751687792494,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}