{"id":"W3167877149","doi":"10.1038/s41467-021-23825-2","title":"Multivalency transforms SARS-CoV-2 antibodies into ultrapotent neutralizers","year":2021,"lang":"en","type":"article","venue":"Nature Communications","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":76,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; Sunnybrook Health Science Centre; The Scarborough Hospital; Hospital for Sick Children; SickKids Foundation; University of Toronto","funders":"National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Canada Research Chairs; National Institutes of Health; Ministry of Colleges and Universities; Hospital for Sick Children; National Cancer Institute; University of Toronto; Sick Kids Foundation; Office of Science; Bill and Melinda Gates Foundation; Argonne National Laboratory; U.S. Department of Energy; European Commission; Canadian Institute for Advanced Research","keywords":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Coronavirus disease 2019 (COVID-19); 2019-20 coronavirus outbreak; Virology; Sars virus; Antibody; Betacoronavirus; Coronavirus Infections; Medicine; Immunology; Outbreak; Infectious disease (medical specialty)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001216073,0.0002987105,0.0001020383,0.000117022,0.0000634378,0.0002318232,0.0001608776,0.0001641474,0.0009649635],"category_scores_gemma":[0.00007785417,0.000081746,0.0001415413,0.00006153747,0.0001415631,0.00014647,0.00024841,0.0003477558,0.0002316056],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002074752,"about_ca_system_score_gemma":0.00008600352,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002916279,"about_ca_topic_score_gemma":0.0002897338,"domain_scores_codex":[0.9999268,0.00001139572,0.000004497784,0.00001756388,0.00001830104,0.0000213149],"domain_scores_gemma":[0.9999669,0.000004816834,0.00001114616,0.000003570059,0.000003782367,0.000009725503],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003350306,0.00001838576,0.00006759548,0.000008541102,0.00000352655,0.00001939406,0.000006785989,0.0001056063,0.998511,0.0001866731,0.00003070825,0.001008302],"study_design_scores_gemma":[0.00001333772,0.0003266934,0.0004936866,0.000001986612,0.000008184905,0.00008738238,0.000006895485,0.000791996,0.9964737,0.00004602282,0.001747818,0.000002180872],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922447,0.0003922083,0.005550752,0.00005314334,0.00002449449,0.00003040923,0.00009451192,0.00008155009,0.001528186],"genre_scores_gemma":[0.9962381,0.000149168,0.002270597,0.00003799409,0.000005668897,0.00001185994,0.00009836253,0.00001249178,0.001175749],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009649635,"threshold_uncertainty_score":0.003228128,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06153156323755555,"score_gpt":0.4078213488061309,"score_spread":0.3462897855685754,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}