{"id":"W3167931457","doi":"10.1371/journal.pgen.1009583","title":"RIOK2 phosphorylation by RSK promotes synthesis of the human small ribosomal subunit","year":2021,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"European Regional Development Fund; CHIST-ERA; Natural Sciences and Engineering Research Council of Canada; Fonds de Recherche du Québec - Santé; Ministère de l'Education Nationale, de l'Enseignement Superieur et de la Recherche; Ligue Contre le Cancer; Conseil Régional Midi-Pyrénées; Canadian Institutes of Health Research; Eidgenössische Technische Hochschule Zürich; Agence Nationale de la Recherche","keywords":"Ribosome biogenesis; Biology; Cell biology; Eukaryotic Small Ribosomal Subunit; Ribosomal s6 kinase; Ribosomal protein; Phosphorylation; MAPK/ERK pathway; Ribosome; Protein kinase A; Eukaryotic Ribosome; Ribosomal protein s6; Biochemistry; Protein phosphorylation; RNA; P70-S6 Kinase 1; Protein kinase B; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004967876,0.00009354229,0.00009161418,0.000009742899,0.0001012854,0.00001641203,0.0001910167,0.000097579,0.0000609888],"category_scores_gemma":[0.0000640401,0.00007928436,0.00007292648,0.00009416446,0.00007267863,0.000001073743,0.00008302257,0.00005258805,0.000003096585],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009713075,"about_ca_system_score_gemma":0.00008134468,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005945898,"about_ca_topic_score_gemma":0.00003860162,"domain_scores_codex":[0.9993216,0.00006087322,0.0001734172,0.0002063967,0.0001134086,0.0001242949],"domain_scores_gemma":[0.9992198,0.00001081283,0.00009336655,0.0004771531,0.0001657472,0.00003314476],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000003693983,0.0001192126,0.005910116,0.00001882983,0.00004708304,2.24589e-7,0.0000291965,0.00002926611,0.9917209,0.00005488837,0.0005836843,0.00148288],"study_design_scores_gemma":[0.0001046044,0.00003558516,0.004633276,0.00001218906,0.00005114142,0.000001874,0.00003623982,0.0001246206,0.9875414,0.00007709569,0.007283278,0.00009869374],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958081,0.002429176,0.0001309026,0.0001934242,0.00004681184,0.0001188119,0.00006614954,0.000005197975,0.001201482],"genre_scores_gemma":[0.9980198,0.0002264152,0.0003980024,0.00006196325,0.00006954832,0.00003267194,0.00006847788,0.0000187317,0.001104427],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006699594,"threshold_uncertainty_score":0.3233123,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01741716758006898,"score_gpt":0.2275463174120707,"score_spread":0.2101291498320017,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}